#NEXUS begin taxa; dimensions ntax=34; taxlabels familyTRPA-geneTRPA1[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPN-geneNompc[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPV-geneTRPV1[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPV-geneTRPV2[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPV-geneTRPV4[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPV-geneTRPV3[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPV-geneTRPV5[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPV-geneTRPV6[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRC-geneTRPC1[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRC-geneTRPC4[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRC-geneTRPC5[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRC-geneTRPC3[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRC-geneTRPC7[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRC-geneTRPC6[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRC-geneTRPC2[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPP-genePK1L1[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPP-genePKD1[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPP-genePK1L2[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPP-genePK1L3[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPP-genePKDREJ[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRM-geneTRPM1[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRM-geneTRPM3[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRM-geneTRPM6[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRM-geneTRPM7[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRM-geneTRPM2[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRM-geneTRPM8[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRM-geneTRPM4[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRM-geneTRPM5[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPP-geneTRPP1[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPP-geneTRPP2[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRPP-geneTRPP3[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRML-geneTRPML1[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRML-geneTRPML2[&Created=Wed Dec 02 20:01:13 PST 2020] familyTRML-geneTRPML3[&Created=Wed Dec 02 20:01:13 PST 2020] ; end; begin characters; dimensions nchar=5147; format datatype=protein missing=? gap=-; matrix familyTRPA-geneTRPA1 -MKRS---------------------------------------------------LRK---------------------------------------------------------------------------MWR-------------PG--EK----------------------KE----------------------------------------------------------------------------------------------------PQGVVY---------------------------------EDVPDDT--------------------------------------------------------------------------------------------------EDFKESLKV-----------------VFEGSAYGLQNFNKQ-------------KKLKRCDDMDTFFLHYAAAEG-----------------------------------------------------------------------------------------QIELMEKITRDSSLEV-----------------------------------LHEMDDYGNTPLHCAVE---------KNQIESVKFLLSRGANPN--------------------------------------------------------------------------------------------------------LRNFNMMAPLH---------------------------IAVQGMN-----------------NEVMKVLLEHRTI------------------------DVNLEGENGNTAVIIA------------------------------------C-----------------TTNN--------------------------------------------------------SEALQI-LLKKGAKPC-------------KSNKWGCFPIHQAAFSGSK-----------ECMEIILRFG---EEH-------------GYSRQ----LH------------INFMNNGK---------------ATPLHL------AVQNG---------------DLEMIKMC---------------------------------------------------LDNGAQIDP--------------------------------------------VEKGRCTAIHFAATQGATEIVKLMI----SSYSGSVDIVNTTDGCHE-------------------------------------------------------------------------------------TMLHRASLFD----------------HH----------------------------EL---------A------------------------------------------------DYLISVGADINKI--------------------DSEGR-------------------------------------------SPLIL----------------------ATASAS-------------------------------------------------------------WNIVNLLLS-----------------------------------------------------------------------------------------KGAQVDIKDNFGRNFLHLT-VQQPYGLKNLR----PEFMQMQQIKELVMDEDNDG--CTPLHYACRQGGPG--SVNNLLGFNVSIHSK--SKDKKSP-------------LHFAASYGRIN-------------------------------------------------------------TCQRLLQDISDTR-------------------------------------------------------------------------------------------------------------------------LLNEG---------------------D-----LHGMTPLHLAAKNGHDK---------------------VVQLLLKKGALFLS------------DHNGWTALHHASMG----GYTQ------------------------------------------TMKVILDTNLKCT--------------------------------DRLDE------------DGNTALHFAAREGHAKAVALLLSH---NADIVLNKQQASFLHLAL-----------------------HNKRKEVVLTIIRSK-----------------------------------------------------------------------RWD----------ECLKIFSHNSPGNKCP-----------ITEMIEY---------------------------LPECM--------------KV--------------------------------------LLDFCM--------------------------------LHSTEDKS-------CRD----------YY--------------------IEYNFKYLQC-----------------------PLEFTKKT----------------------------------------------------------P------TQDVIYEPLTALNAMVQNN--------------RIELLN--------------HPVCKEYLLMKWL----------------------------------------------AYGFRA----------------------HMMNLG--SYCLGLIPM------------------TILVV-----------------NIKPGMAFNSTGI----------------------------------------------------------------INET------SD-------HSEILDTTNSYL---IKTCM-----------------------ILVFLSSIFGYCKEAGQ----------------------------------------IF----------------------------------------------------------------------------------------------------------------------------------QQKRNYFM---------------------------DISNVLEWIIYTTGIIFVLPLFVEI-------------------------------------------------------------PA------HLQ--------WQCGAIAVYFYW-------------------------------------MNFLLYLQRFENCGIFIV----------MLEVILKT-LLR-------STVVFIFLLLA---------------------------FGLSFY----------ILL---------------------------------NLQDPFSSPLLSIIQTFSMM----LGDINYRESFL-----------------EP------------YLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAV----------------------GDIAEVQK-------HASLK---------------------------------------------------------------------RIAMQV------------ELHTSLEKKL----------------------------------------------------------------------------------------------PL----------------WFLRKVDQKSTIVYPNKPRS---------------------GGMLFHIF-----------------CFLFCTGEIRQEI-------------PNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLI------IQKMEIISETEDDDSHCSFQD--------------RFKKEQMEQRNSRWNTVLRAVKAK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THHLE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P------------------ familyTRPN-geneNompc -MSESSCVSGAPQRL-------------------------------------VPLALRG---------------------------------------------------------------------------EWMALEQKIKTLERGDPDILQC----------------------DE----------------------------------------------------------------------------------------------------ESGMSLLMLAVR--E--------SRLSVLDRLLEL----GANPSDKT-------------------------------------------------------------------------------------------------KDGRSALHIAAAHSK--------------DEIVKLLVRKTD-------------PNSPA-GPNDQLPLHYAASRST--------GGLAVVQ-TLLKFSSKDARLTPDKNGCLPLLLAAEAGNVGIVR----------------------------ELLSSQSEPQIRAAKTANGDTALHICCRRRDV----------------EMAKILVEFGANPDSQNDEGQTPLHIAAH---------EGDENMLKFLYLCKANAN--------------------------------------------------------------------------------------------------------ISDKMDRSPLH---------------------------IAAERGH-----------------TNVVEILTEKFRSCVLA------------------------RTKDGNTLLHIASQ----------------------------------CG---HPT----TALS-FLRKGV-PLHMPNKSGAV--------------------------CLHA--------AAKRGHTAVVKALLQKGAHVD-------------AAARDGQTALHIAVENCRP-----------QVVQMLLGFG---AHV----QL-----RGGKAQETPLHISAR--VKEGERAAEMLLKSGAEVNAEQEN------GETALHV------AARHG---------------SLQMIRAL---------------------------------------------------IQEGGDP--------------------------RWR------------------SRVGESPLHVAVRHCHAHVVQEILTFLTNEKSRRDAELCVCEGNQD-----------------------------------------------------------------------------------GETALHLAAELRTDAL------------HQ----------------------------------------PE------------------EDITII----------------------QILMEHQADITAVT-------------------RQTGE-------------------------------------------TPLHYSARVG---------------NTAVLQEM-------LRNVPTNQIQTAI----------NKHSKNGWS------------PLLLAADQGHTEVVKILLQ-----------------------------------------------------------------------------------------NNARVDVFDEEGKAAIHLA-AQRGHQDIVDVLLSQKAFVNAKTKQGLT-----------PLHLSAQNGSAR--LVRLLVENHQASVDA-LSLRKQTP-------------LHLAAMSGQLD----------------------------------------------------------VCSSLLNLRADITATDS---------RGQTPLHLAAESDHSEVV------------------------------------KLFLRLRPELSTLANE-------------------D--GSTCTHIAAAKG----SVSVIRELLMF----------NQGGVGTLNH---KAHGLCPLHLAAAGGHAE---------------------VVKVLLEAGASVTEE-----------DAEGMTAVHLAAKH----GHTHILEVLRGSV----------PLKIQSSKTGFTALHV---AASFGQMNFVREILTKVPATIR-SEFPTI-----------------SGKDDIKRQ------QPLAESGFTPLHLASQSGHESVVRLLLNCPGVQADAETNIQGSSPLHLAAQSGHTAVVGLLLSRSSSLLHQADRRGRSALHLAAAHGH---VDMVRVLLGQGAEI-----------------------------------------------NHTDMS-GWT---------------ALHYAAEAGCLE----------VLLFLVES---------GASACAE--CHG-GRTPLQYAAQQNHESAVIFLL--RR-EKNTL--------RLLDDKKFIFNLMVCGRMN-DNLSLEELVL-HTSAPLDTAVRLSRAL--------------TLCALREKE------------------------------------------RSVDLQAAAHH---------------------CELMASDLL--------------------------SLSASAG-------GQGAG-----------AGPI-----LRALDHRGLSVLDCLIEGR--------------QKGVVS--------------QPAVQTYLTEVWC-------------GGL------------------------------QWDSWK----------------------ILLLFCCLLLCPPL--------------------WLLLAL--------------------PLTHSFNT----------------------------------------------------------------------------IP-------IVKFMSHLVSHI-----FLL-----------------------TLFILTIVYPPVSPLSQA----RLMPSWSEC--------------------------LL-----------------------------------------------------------------------LIW--------------------------------------------LCGMLVSELT----------FPGER----------------------TGLAWIRLLLLGFSAAALLCHLLAV------------------------------------------------FTQWW-------PPT------HLHCL---FARNVLLAVAMTLGF-------------------------------------IQLLEFLTFHHLFGPWAI----------IIRDLIKD-LCR-------FAVILMLFHTA---------------------------FTLSLT----------ALC----QPLYPQEQHN---TTT-----------EVTVPGPLNMSVLLFFALFGLTEPDKIPDVDRSPP---------------------------------------ATAVLAKMVFGVYLVVTFIVLINLLIAMMS----------------------DTYQRIQA-------QSDTE-----------------------------------------------------W---------------KFGRA-------------VLIRDMSRKSG--------------------------------------------IP----------------------------------------------SPFN----------------------------------------------------------LFTNLFY---------------SVKVVCKRA---------------------GKMCSSESRDVMNEDEDAEGLSESRSLDLL-----------SQASVSGIRGNKRTQILPEGGQISLA------HSGGHVRVENVADWPSVVQQFLSQ--------------------------RRQRDRSTAERDE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- familyTRPV-geneTRPV1 -MKKWSSTDLG---------------------------------------------------------------------------------------------------------------------------------------AAADPL---------------------------------------------------------------------------------------------------------------------------------QKD-------------------------TCPDPL----DGDPNSRP-------------------------------------------------------------------------------------------------PPAKPQLSTAKSRTR-----------LF-GKGDSEEAFPVD-------------CPHEE-GELDSCPTITVSPVI-TIQRPG------------------DGPTGA-----------RLLSQDS-----------------------------------------------------VA--------------------------------ASTEKT-LRLYDRRSIFEAVA---------QNNCQDLESLLLFLQKSK--------------------------------------------------------------------------------------------------------------------------------------------------------KHLTD---------NEFKD-------------------------------------PETGKTCL---------------------------------------------------------------------------------------------------------------------LKAML--NLHDG------------------QN---------------------------TTIPLLLEIA---RQT-------------DSLKE----------LVNASYTDSYYKGQ------------------TALHI------AIERR---------------NMALVTLL---------------------------------------------------VENGADV--------------------------QAA------------------AHG--------------------------------------------------------------------------------------------------------------------------------DFFK-KTKGR----------------------------------------------------------------------------------------------------------------PG-------------------------FYFGE-------------------------------------------LPLSL----------------------AACTNQ-------------------------------------------------------------LGIVKFLLQNSW--------------------------------------------------------------------------------------QTADISARDSVGNTVLHAL-VEVADNTADN----------TKFVTSMY---------------------------NEILMLG----------------------------AKLHP-TLKLE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELTN----------------------------KKGMTPLALAAGTGKIG---------------------VLAYILQREIQEP------------------ECRHLSRKF---------------------------------------------------------------------------------------------------T----------------------------------------------------------------------------------------------------------------------------------------------------------------------EWAY-GP---------------------------------VHSSLYD---------------------------LSCID--------------TC-EKNS---------------------------------VLEVIA--------------------------------YSSSETPN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHDMLL--------------VEPLNRLLQDKWD----------------------------------------------RFVKRI----------------------FYFNFL--VYCLYMIIF------------------TMAAY------------------YRPV--------------------------------------------------------------------------DG------LP--------PFKMEKTGDYF-----RVTGE---------------------ILSVLGGVYFFFRGIQ-----------------------------------------YF-----------------------------------------------------------------------------------------------------------------------------------LQRRPSMKTL------------------------FVDSYSEMLFFLQSLFMLATVVLYF---------------------------------------------------------------------SHLKE-----YVASMVFSLALGW-------------------------------------TNMLYYTRGFQQMGIYAV----------MIEKMILRDLCR-------FMFVYIVFLFG---------------------------FSTAVV----------TLI----EDGKNDSLPSE--STSHRWRGPACRPPD----SSYNSLYSTCLELFKFT--IGMGDLEFTEN--------------------------Y------------DFKAVFIILLLAYVILTYILLLNMLIALMG----------------------ETVNKIAQ-------ESKNI-----------------------------------------------------W---------------KLQRA-------------ITILDTEKSF----------------------------------------------------------------------------------------------LK-----------------------------------------------------------CMRKAFR----------------SGKLLQVG---------------------YTPDGKDDYRWCFRVDEVNWTTWNTNVGII------------------NEDPGNCE-----GVKRTLSFS----LRSSRVSGRHWKNFALVPLLREA---------------------------SARDRQSAQPEE-VYLRQFS-------------------------------------------------------------GS---------------------------------------------------------------------------------------------------------------------------------------------------------------------LK--------------------------------------------------------PEDAEVFKS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAASGEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- familyTRPV-geneTRPV2 -MTSPSSS----------------------------------------------------------------------------------------------------------------------------------------------PV---------------------------------------------------------------------------------------------------------------------------------FR----------------------------LETL----DGGQEDGS-------------------------------------------------------------------------------------------------EADRGKLD-------------------F-GSGLP----PME-------------SQFQG-EDRKFAPQIRVN----LNYRKG------------------TG-------------------------------------------------------------------------------------------------------------ASQPDP-NR-FDRDRLFNAVS---------RGVPEDLAGLPEYLSKTS--------------------------------------------------------------------------------------------------------------------------------------------------------KYLTD---------SEYTE-------------------------------------GSTGKTCL---------------------------------------------------------------------------------------------------------------------MKAVL--NLKDG------------------VN---------------------------ACILPLLQID---RDS-------------GNPQP----------LVNAQCTDDYYRGH------------------SALHI------AIEKR---------------SLQCVKLL---------------------------------------------------VENGANV--------------------------HAR------------------ACG--------------------------------------------------------------------------------------------------------------------------------RFFQ-KGQG-----------------------------------------------------------------------------------------------------------------TC-------------------------FYFGE-------------------------------------------LPLSL----------------------AACTKQ-------------------------------------------------------------WDVVSYLLENPH--------------------------------------------------------------------------------------QPASLQATDSQGNTVLHAL-VMISDNSAEN----------IALVTSMY---------------------------DGLLQAG----------------------------ARLCP-TVQLE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIRN----------------------------LQDLTPLKLAAKEGKIE---------------------IFRHILQREFS--------------------GLSHLSRKF---------------------------------------------------------------------------------------------------T----------------------------------------------------------------------------------------------------------------------------------------------------------------------EWCY-GP---------------------------------VRVSLYD---------------------------LASVD--------------SC-EENS---------------------------------VLEIIA--------------------------------F-HCKSPH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHRMVV--------------LEPLNKLLQAKWD----------------------------------------------LLIPK-----------------------FFLNFL--CNLIYMFIF------------------TAVAY------------------HQPTL----------------------------------------------K-------------------------KQA------AP--------HLKAE-VGNSM-----LLTGH---------------------ILILLGGIYLLVGQLW-----------------------------------------YF-----------------------------------------------------------------------------------------------------------------------------------WRRHVFIWIS------------------------FIDSYFEILFLFQALLTVVSQVLCF---------------------------------------------------------------------LAIEW-----YLPLLVSALVLGW-------------------------------------LNLLYYTRGFQHTGIYSV----------MIQKVILRDLLR-------FLLIYLVFLFG---------------------------FAVALV----------SLS----QEAWRPEAPTG--PNATESVQPMEGQEDEGNGAQYRGILEASLELFKFT--IGMGELAFQEQ--------------------------L------------HFRGMVLLLLLAYVLLTYILLLNMLIALMS----------------------ETVNSVAT-------DSWSI-----------------------------------------------------W---------------KLQKA-------------ISVLEMENGY----------------------------------------------------------------------------------------------WW-----------------------------------------------------------C-RKKQR----------------AGVMLTVG---------------------TKPDGSPDERWCFRVEEVNWASWEQTLPTL------------------CEDPSGA------GVPRTL------------------EN----PVLASP---------------------------PKEDEDGAS-EE-NYV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVQLLQS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- familyTRPV-geneTRPV4 -MADSSEG----------------------------------------------------------------------------------------------------------------------------------------------PR---------------------------------------------------------------------------------------------------------------------------------AGP-------------------------GEVAEL----PGDESGTP-------------------------------------------------------------------------------------------------GGEAFPLS---SLAN-----------LFEGEDGSLSPSPAD-------------ASRPA-GPGDGRPNLRMK-FQ-GAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDNKRWRK-------------------------------------KIIEKQPQSPKAP--------------------------------APQPPPILKVFNRPILFDIVS---------RGSTADLDGLLPFLLTHK--------------------------------------------------------------------------------------------------------------------------------------------------------KRLTD---------EEFRE-------------------------------------PSTGKTCL---------------------------------------------------------------------------------------------------------------------PKALL--NLSNG------------------RN---------------------------DTIPVLLDIA---ERT-------------GNMRE----------FINSPFRDIYYRGQ------------------TALHI------AIERR---------------CKHYVELL---------------------------------------------------VAQGADV--------------------------HAQ------------------ARG--------------------------------------------------------------------------------------------------------------------------------RFFQPKDEG-----------------------------------------------------------------------------------------------------------------GY-------------------------FYFGE-------------------------------------------LPLSL----------------------AACTNQ-------------------------------------------------------------PHIVNYLTENPH--------------------------------------------------------------------------------------KKADMRRQDSRGNTVLHAL-VAIADNTREN----------TKFVTKMY---------------------------DLLLLKC----------------------------ARLFP-DSNLE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVLN----------------------------NDGLSPLMMAAKTGKIG---------------------IFQHIIRREVTDE------------------DTRHLSRKF---------------------------------------------------------------------------------------------------K----------------------------------------------------------------------------------------------------------------------------------------------------------------------DWAY-GP---------------------------------VYSSLYD---------------------------LSSLD--------------TCGEEAS---------------------------------VLEILV--------------------------------Y-NSKIEN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHEMLA--------------VEPINELLRDKWR----------------------------------------------KFGAVS----------------------FYINVV--SYLCAMVIF------------------TLTAY------------------YQPL--------------------------------------------------------------------------EG------TP--------PYPYRTTVDYL-----RLAGE---------------------VITLFTGVLFFFTNIKD----------------------------------------LF-----------------------------------------------------------------------------------------------------------------------------------MKKCPGVNSL------------------------FIDGSFQLLYFIYSVLVIVSAALYL---------------------------------------------------------------------AGIEA-----YLAVMVFALVLGW-------------------------------------MNALYFTRGLKLTGTYSI----------MIQKILFKDLFR-------FLLVYLLFMIG---------------------------YASALV----------SLL----NPCANMKVCNEDQTNCTVPTYPSCRDSE-----TFSTFL---LDLFKLT--IGMGDLEMLSS--------------------------T------------KYPVVFIILLVTYIILTFVLLLNMLIALMG----------------------ETVGQVSK-------ESKHI-----------------------------------------------------W---------------KLQWA-------------TTILDIERSF----------------------------------------------------------------------------------------------PV-----------------------------------------------------------FLRKAFR----------------SGEMVTVG---------------------KSSDGTPDRRWCFRVDEVNWSHWNQNLGII------------------NEDPGKNETYQYYGFSHTV----------GRLRRDRWSS--VVPRVVEL---------------------------NK----NSNPDE-VVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLDSMGN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRCDGHQQGY-----------------------------------------------------------------PRKW--------------------------------------------RTDDA-------------------------------------------PL----------------- familyTRPV-geneTRPV3 -MKAHPKEMV--------------------------------------------------------------------------------------------------------------------------------------------PL---------------------------------------------------------------------------------------------------------------------------------MGK-------------------------R-VAAP----SGNPAILP-------------------------------------------------------------------------------------------------EKRPAEITPTKKSAH-----------FF-LEIEGFEPNPTV-------------A--------KTSPPVFSKPMD-SNIRQCISGNCDDM----------DSPQSP---------------QDD--------------------------------------------VTETPSNPNSP----------------------------SAQLAKEEQRRKKRRLKKRIFAAVS---------EGCVEELVELLVELQELC--------------------------------------------------------------------------------------------------------------------------------------------------------RRRHD---------EDVPDFLMHKLT-----------------------------ASDTGKTCL---------------------------------------------------------------------------------------------------------------------MKALL--NINPN------------------TK---------------------------EIVRILLAFA---EEN-------------DILGR----------FINAEYTEEAYEGQ------------------TALNI------AIERR---------------QGDIAALL---------------------------------------------------IAAGADV--------------------------NAH------------------AKG--------------------------------------------------------------------------------------------------------------------------------AFFNPKYQH-----------------------------------------------------------------------------------------------------------------EG-------------------------FYFGE-------------------------------------------TPLAL----------------------AACTNQ-------------------------------------------------------------PEIVQLLME--H--------------------------------------------------------------------------------------EQTDITSRDSRGNNILHAL-VTVAEDFKTQ----------NDFVKRMY---------------------------DMILLRS----------------------------GNW-----ELE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTRN----------------------------NDGLTPLQLAAKMGKAE---------------------ILKYILSREIKEK------------------RLRSLSRKF---------------------------------------------------------------------------------------------------T----------------------------------------------------------------------------------------------------------------------------------------------------------------------DWAY-GP---------------------------------VSSSLYD---------------------------LTNVD--------------TT-TDNS---------------------------------VLEITV--------------------------------Y-NTNIDN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHEMLT--------------LEPLHTLLHMKWK----------------------------------------------KFAKHM----------------------FFLSFC--FYFFYNITL------------------TLVSY------------------YRPR-----------------------------------------------E-------------------------EEA------IP-------HPLALTHKMGWL-----QLLGR---------------------MFVLIWAMCISVKEGIA----------------------------------------IF-----------------------------------------------------------------------------------------------------------------------------------LLRPSDLQSI------------------------LSDAWFHFVFFIQAVLVILSVFLYL---------------------------------------------------------------------FAYKE-----YLACLVLAMALGW-------------------------------------ANMLYYTRGFQSMGMYSV----------MIQKVILHDVLK-------FLFVYIVFLLG---------------------------FGVALA----------SLI----EKCPKDN------KDC----------------SSYGSFSDAVLELFKLT--IGLGDLNIQQN--------------------------S------------KYPILFLFLLITYVILTFVLLLNMLIALMG----------------------ETVENVSK-------ESERI-----------------------------------------------------W---------------RLQRA-------------RTILEFEKML----------------------------------------------------------------------------------------------PE-----------------------------------------------------------WLRSRFR----------------MGELCKV--------------------------AEDDFRLCLRINEVKWTEWKTHVSFL------------------NEDPG--------PVRRT-----------------------------DF---------------------------NKIQDSSRNNSK-TTLNAF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEVEEFPE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- familyTRPV-geneTRPV5 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG-GFLPKA------------------EGPGSQ-LQKLLPSFLVREQDWDQHL-------------------------------------------------------------------------------------DKLHMLQQKRILESPLLRASK---------ENDLSVLRQLLLD----------------------------------------------------------------------------------------------------------------------------------------------------------------CT---------CDVRQ------------------------------------RGALGETAL---------------------------------------------------------------------------------------------------------------------HIAALYDNL--------------------------------------------------EAALVLMEAA---PE-----------------------------LVFEPTTCEAFAGQ------------------TALHI------AVVNQ---------------NVNLVRAL---------------------------------------------------LTRRASV--------------------------SAR------------------ATG--------------------------------------------------------------------------------------------------------------------------------TAFR-RSPR-----------------------------------------------------------------------------------------------------------------NL-------------------------IYFGE-------------------------------------------HPLSF----------------------AACVNS-------------------------------------------------------------EEIVRLLIE-----------------------------------------------------------------------------------------HGADIRAQDSLGNTVLHIL-IL-----QPN----------KTFACQMY---------------------------NLLLSYD----------------------------GHGDH-LQPLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVPN----------------------------HQGLTPFKLAGVEGNTV---------------------MFQHLMQK-----------------------------RRH---------------------------------------------------------------------------------------------------I----------------------------------------------------------------------------------------------------------------------------------------------------------------------QWTY-GP---------------------------------LTSILYD---------------------------LTEID--------------SWGEELS---------------------------------FLELVV----------------------------------SSDKRE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ARQILE--------------QTPVKELVSFKWN----------------------------------------------KYGRPY----------------------FCILAA--LYLLYMICF------------------TTCCV------------------YRPL-----------------------------------------------KF----------RGGNRTHSRDITILQQK------LL--------QEAYETREDII-----RLVGE---------------------LVSIVGAVIILLLEIPD----------------------------------------IF----------------------------------------------------------------------------------------------------------------------------------RVGASRYFGKT------------------------ILGGPFHVIIITYASLVLVTMVMRL---------------------------------------------------------------------TNTNG-----EVVPMSFALVLGW-------------------------------------CSVMYFTRGFQMLGPFTI----------MIQKMIFGDLMR-------FCWLMAVVILG---------------------------FASAFY----------IIF----QTEDPTSL------------------------GQFYDYPMALFTTFELF--LTVIDAPANYD--------------------------V------------DLPFMFSIVNFAFAIIATLLMLNLFIAMMG----------------------DTHWRVAQ-------ERDEL-----------------------------------------------------W---------------RAQVV-------------ATTVMLERKL----------------------------------------------------------------------------------------------PR-----------------------------------------------------------CLWP--R----------------SG----IC---------------------GCEFGLGD-RWFLRVENHNDQNPLRVLRYV-----------EVFKNSDKEDDQEH------PSEKQP---------SGAESGTLARASLALPTSSLS---------------------------RTASQSSSHRGW-EILRQNTL------------------------------------------------------------GH---------------------------------------------------------------------------------------------------------------------------------------------------------------------LN---------------------------------------------------------LGLNL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGDGEE-VY-----------------------------------------------------------------HF----------------------------------------------------------------------------------------------------------------- familyTRPV-geneTRPV6 -MG---------------------------------------------------------------------------------------------------------------------------------------------------PL---------------------------------------------------------------------------------------------------------------------------------QG------------------------------------DGGPALGG-------------------------------------------------------------------------------------------------ADVAPRLSP----VR-----------VW--------PRPQA-------------PKEPA-----------LHPMG-LSLPKE------------------KGLILC-LWSKFCRWFQRRESWAQSR-------------------------------------------------------------------------------------DEQNLLQQKRIWESPLLLAAK---------DNDVQALNKLLKY----------------------------------------------------------------------------------------------------------------------------------------------------------------ED---------CKVHQ------------------------------------RGAMGETAL---------------------------------------------------------------------------------------------------------------------HIAALYDNL--------------------------------------------------EAAMVLMEAA---PE-----------------------------LVFEPMTSELYEGQ------------------TALHI------AVVNQ---------------NMNLVRAL---------------------------------------------------LARRASV--------------------------SAR------------------ATG--------------------------------------------------------------------------------------------------------------------------------TAFR-RSPC-----------------------------------------------------------------------------------------------------------------NL-------------------------IYFGE-------------------------------------------HPLSF----------------------AACVNS-------------------------------------------------------------EEIVRLLIE-----------------------------------------------------------------------------------------HGADIRAQDSLGNTVLHIL-IL-----QPN----------KTFACQMY---------------------------NLLLSYD----------------------------RHGDH-LQPLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVPN----------------------------HQGLTPFKLAGVEGNTV---------------------MFQHLMQK-----------------------------RKH---------------------------------------------------------------------------------------------------T----------------------------------------------------------------------------------------------------------------------------------------------------------------------QWTY-GP---------------------------------LTSTLYD---------------------------LTEID--------------SSGDEQS---------------------------------LLELII----------------------------------TTKKRE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ARQILD--------------QTPVKELVSLKWK----------------------------------------------RYGRPY----------------------FCMLGA--IYLLYIICF------------------TMCCI------------------YRPL-----------------------------------------------KP----------RTNNRTSPRDNTLLQQK------LL--------QEAYMTPKDDI-----RLVGE---------------------LVTVIGAIIILLVEVPD----------------------------------------IF----------------------------------------------------------------------------------------------------------------------------------RMGVTRFFGQT------------------------ILGGPFHVLIITYAFMVLVTMVMRL---------------------------------------------------------------------ISASG-----EVVPMSFALVLGW-------------------------------------CNVMYFARGFQMLGPFTI----------MIQKMIFGDLMR-------FCWLMAVVILG---------------------------FASAFY----------IIF----QTEDPEEL------------------------GHFYDYPMALFSTFELF--LTIIDGPANYN--------------------------V------------DLPFMYSITYAAFAIIATLLMLNLLIAMMG----------------------DTHWRVAH-------ERDEL-----------------------------------------------------W---------------RAQIV-------------ATTVMLERKL----------------------------------------------------------------------------------------------PR-----------------------------------------------------------CLWP--R----------------SG----IC---------------------GREYGLGD-RWFLRVEDRQDLNRQRIQRYA-----------QAFHTRGSEDLDKD------SVEK-------------LELGCPFSPHLSLPMPSVS---------------------------RSTSRSSAN--W-ERLRQGTLRRD-------------------L------------------------------------RGI---------------------------------------------------------------------------------------------------------------------------------------------------------------------IN---------------------------------------------------------RGLE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGESWEY-----------------------------------------------------------------QI----------------------------------------------------------------------------------------------------------------- familyTRC-geneTRPC1 MMAALYPSTD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSGA-------------------------------------------------------------------------------------------------------------SSSSLPSSPSSS-------------------------------------------------------------SPNEVMALKDVREVKEENT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LNEK----------------------------------------LFLL-------ACDKG---------------DYYMVKKI---------------------------------------------------LEENS-S--------------------------------------------------GDLNINC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD-----------------------------VLGR-------------------------------------------NAVTI----------------------TIENEN-------------------------------------------------------------LDILQLLLDYGC-----------------------------------------------------------------------------------------------QSADALLVAI---------------------DSEVVGAV---------------------------DILLNHR-----------------------------PKRSSRPTIV----------------------------------------------------------------KLMERIQNPE------------------------------------------------------------------YST------------------------------------------------------------------------------------TMDVAPVILAAHRNNYE---------------------ILTMLLKQDVS------------------------LPKPH-----------------------------------------------------AVGCECTLCSAKNKK---------------------------DSLRH----------------------SRFRLDIYRCLASPA-------------------------------------L-------------------------------------------------------------------------------------------------------------IMLTEEDP--------------ILRAFEL------------------------SADLKELS--------------LV-EVEF--------------RND----------------YEELAR-QCKM---FAKDL-------------------LAQARNSR---------------------------------------------ELEVI--------------------------LNHTSS------------------------DE-PLDKR----------------------------------GLLEERMNLSRLKLAIKYN--------------QKEFVS--------------QSNCQQFLNTVWF-------------GQMSGY---------------------------RRKPTC----------------------KKIMTV-----------------------------LTVGI------------------FWPVLSLCYLIA---------------------------------------------------------PKSQFGRIIH-------TP-------FMKFIIHGASYF-----TFL-----------------------LLLNLYSLVYNEDKKNTM----GPALERIDY--------------------------LL-----------------------------------------------------------------------ILW--------------------------------------------IIGMIWSDI------KRLWYEGLED----------------------FLEESRNQLSFVMNSLYLATFALKV----VAH---------------------------NKFHDFA-------DRKDWD----AFHPT------LVAEG--------LFAFANVLSY-------------------------------------LRLFFMYTTSSILGPLQI----------SMGQMLQD-FGK-------FLGMFLLVLFS---------------------------FTIGLT----------QLYDK--GYTSKEQK------DCVGIF--CEQQSNDTFHSFIGTCFALFWYIFSLA------HVAIFVTRF-------------------------------SYGEELQ-SFVGAVIVGTYNVVVVIVLTKLLVAMLH----------------------KSFQLIAN-------HEDKE-----------------------------------------------------W---------------KFARA-------------KLWLSYFDDKC-------------------------------------------TLP----------------------------------------------PPF-------------------------NIIPSPKTIC------------------------YMISSL-----------------SKWICS--------------------------HTSK-GKVKRQN----SLKEWRN------------------------------------------------LKQKRDENYQKVMCCLVHRYLTS----------MRQKMQSTDQATVENLN-ELRQDLSKFRN-EIRDLLGFRT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKYAM------------FYPRN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ familyTRC-geneTRPC4 -MAQFYYKRN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNAP-------------------------------------------------------------------------------------------------------------YRDRIP--------------------------------------------------------------------------LRIVR-AESELS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSEK----------------------------------------AYLN-------AVEKG---------------DYASVKKS---------------------------------------------------LEEAEIY--------------------------------------------------FKININC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ID-----------------------------PLGR-------------------------------------------TALLI----------------------AIENEN-------------------------------------------------------------LELIELLLSFNV-----------------------------------------------------------------------------------------------YVGDALLHAI---------------------RKEVVGAV---------------------------ELLLNHK------------------------------KPSGEKQVP----------------------------------------------------------------PILLDKQFSE------------------------------------------------------------------F--------------------------------------------------------------------------------------TPDITPIILAAHTNNYE---------------------IIKLLVQKGVS------------------------VPRPH-----------------------------------------------------EVRCNCVECVSSSDV---------------------------DSLRH----------------------SRSRLNIYKALASPS-------------------------------------L-------------------------------------------------------------------------------------------------------------IALSSEDP--------------FLTAFQL------------------------SWELQELS--------------KV-ENEF--------------KSE----------------YEELSR-QCKQ---FAKDL-------------------LDQTRSSR---------------------------------------------ELEII--------------------------LNYRDD------------------------NS-LIEE--------------------------------------QSGNDLARLKLAIKYR--------------QKEFVA--------------QPNCQQLLASRWY-------------DEFPGW---------------------------RRRHWA----------------------VKMVTC-----------------------------FIIGL------------------LFPVFSVCYLIA---------------------------------------------------------PKSPLGLFIR-------KP-------FIKFICHTASYL-----TFL-----------------------FLLLLASQHIDRSDLNRQ----GPPPTIVEW--------------------------MI-----------------------------------------------------------------------LPW--------------------------------------------VLGFIWGEI------KQMWDGGLQD----------------------YIHDWWNLMDFVMNSLYLATISLKI----VAF---------------------------VKYSALN-------PRESWD----MWHPT------LVAEA--------LFAIANIFSS-------------------------------------LRLISLFTANSHLGPLQI----------SLGRMLLD-ILK-------FLFIYCLVLLA---------------------------FANGLN----------QLY-----FYYEETKGL----TCKGIR--CEKQ-NNAFSTLFETLQSLFWSIFGL--------INLYVTNV-------------------------------KAQHEFT-EFVGATMFGTYNVISLVVLLNMLIAMMN----------------------NSYQLIAD-------HADIE-----------------------------------------------------W---------------KFART-------------KLWMSYFEEGG-------------------------------------------TLP----------------------------------------------TPF-------------------------NVIPSPKSLW------------------------YLIKWI-----------------WTHLCK-------------------------------KKMRRKPESFGTIGRRAA------------------------------------------------DNLRRHHQYQEVMRNLVKRYVAA----------MIRDAKTEEGLTEENFK-ELKQDISSFRF-EVLGLLRGSKL---------------------------------------STI-QSANASKESSN--------------------------------------------------------------------------SADSDEKS------------------------------D---SEGN-----------------------SKDKKKNFSLFDLTTLI--HPRSAAIASERHNISNGSALVVQEPPR-------EKQR-------KVNFVT-----------------DIKNFGL------------FHRRSKQNAAEQNANQIFSVSEEVAR-------------------------------------------------------------------------------------QQAA-GPLERNIQLESR-GLASRGDLSIPGLSEQCV----------------------------LVDHRERNTDTLG---------------------LQVGKRV----------------------------------------------CPFKSE-------------KVV-VEDTVPI--------------------------------------------------------------------------------IPKEKHAKEEDS----------------------------SIDY----DLNL-PDTVTH---------------------------------------EDYVTTRL------------------------------------------------------------------------------------- familyTRC-geneTRPC5 -MAQLYYKKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYSP-------------------------------------------------------------------------------------------------------------YRDRIP--------------------------------------------------------------------------LQIVR-AETELS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEEK----------------------------------------AFLN-------AVEKG---------------DYATVKQA---------------------------------------------------LQEAEIY--------------------------------------------------YNVNINC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MD-----------------------------PLGR-------------------------------------------SALLI----------------------AIENEN-------------------------------------------------------------LEIMELLLNHSV-----------------------------------------------------------------------------------------------YVGDALLYAI---------------------RKEVVGAV---------------------------ELLLSYR------------------------------RPSGEKQVP----------------------------------------------------------------TLMMDTQFSE------------------------------------------------------------------F--------------------------------------------------------------------------------------TPDITPIMLAAHTNNYE---------------------IIKLLVQKRVT------------------------IPRPH-----------------------------------------------------QIRCNCVECVSSSEV---------------------------DSLRH----------------------SRSRLNIYKALASPS-------------------------------------L-------------------------------------------------------------------------------------------------------------IALSSEDP--------------ILTAFRL------------------------GWELKELS--------------KV-ENEF--------------KAE----------------YEELSQ-QCKL---FAKDL-------------------LDQARSSR---------------------------------------------ELEII--------------------------LNHRDD------------------------HSEELDP--------------------------------------QKYHDLAKLKVAIKYH--------------QKEFVA--------------QPNCQQLLATLWY-------------DGFPGW---------------------------RRKHWV----------------------VKLLTC-----------------------------MTIGF------------------LFPMLSIAYLIS---------------------------------------------------------PRSNLGLFIK-------KP-------FIKFICHTASYL-----TFL-----------------------FMLLLASQHIVRTDLHVQ----GPPPTVVEW--------------------------MI-----------------------------------------------------------------------LPW--------------------------------------------VLGFIWGEI------KEMWDGGFTE----------------------YIHDWWNLMDFAMNSLYLATISLKI----VAY---------------------------VKYNGSR-------PREEWE----MWHPT------LIAEA--------LFAISNILSS-------------------------------------LRLISLFTANSHLGPLQI----------SLGRMLLD-ILK-------FLFIYCLVLLA---------------------------FANGLN----------QLY-----FYY-ETRAIDEPNNCKGIR--CEKQ-NNAFSTLFETLQSLFWSVFGL--------LNLYVTNV-------------------------------KARHEFT-EFVGATMFGTYNVISLVVLLNMLIAMMN----------------------NSYQLIAD-------HADIE-----------------------------------------------------W---------------KFART-------------KLWMSYFDEGG-------------------------------------------TLP----------------------------------------------PPF-------------------------NIIPSPKSFL------------------------YLGNWF-----------------NNTFCP--------------------------KRDPDGRRRRRNL--RSFTERNA------------------------------------------------DSLIQNQHYQEVIRNLVKRYVAA----------MIRNSKTHEGLTEENFK-ELKQDISSFRY-EVLDLLGNRK--------------------------------------------HPRSFSTSSTE--------------------------------------------------------------------------LSQRDDNN------------------------------D---GSGG-----------------------ARAKSKSVS-FNLGC--------------KKKTCHGPPL-IRTMPRSSGAQGKSKAE-------SSSKRSFM-------------GPSLKKLGL------------LFSKFNGHMSEPSSEPMYTISDGIVQ-------------------------------------------------------------------------------------QHCM-WQDIRYSQME-K-GKAEACSQSEINLSEVELG---------------------------EVQGAAQSSE-----------------------------------------------------------------------------CPLACS-------------SSLHCASSIC------------------------------------------------------------------------------------SSNSKLLDS----------------------------SEDVFETW-GEA-CDLLMHKWG----D------------G-----------------QEEQVTTRL------------------------------------------------------------------------------------- familyTRC-geneTRPC3 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MREKGRRQA------------------------------------------------------------------------------------------------------VRGPAFMFN------------------------------------------------------------------------------------------------DRGTSLT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEEE----------------------------------------RFLD-------AAEYG---------------NIPVVRKM---------------------------------------------------LEES-----------------------------------------------------KTLNVNC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD-----------------------------YMGQ-------------------------------------------NALQL----------------------AVGNEH-------------------------------------------------------------LEVTELLLK---------------------------------------------------------------------------------------------KENLARIGDALLLAI---------------------SKGYVRIV---------------------------EAILNHP------------------------------GFAASKRL--------------------------------------------------------------TLSPCEQELQDDD------------------------------------------------------------------FYAY----------------------------------------------------DEDGTRF------------------------SPDITPIILAAHCQKYE---------------------VVHMLLMKGAR------------------------IERPH-----------------------------------------------------DYFCKCGDCMEKQRH---------------------------DSFSH----------------------SRSRINAYKGLASPA-------------------------------------Y-------------------------------------------------------------------------------------------------------------LSLSSEDP--------------VLTALEL------------------------SNELAKLA--------------NI-EKEF--------------KND----------------YRKLSM-QCKD---FVVGV-------------------LDLCRDSE---------------------------------------------EVEAI--------------------------LNGDLE------------------------SAEPLEV-------------------------------------HRHKASLSRVKLAIKYE--------------VKKFVA--------------HPNCQQQLLTIWY-------------ENLSGL---------------------------REQTIA----------------------IKCLVV-----------------------------LVVAL------------------GLPFLAIGYWIA---------------------------------------------------------PCSRLGKILR-------SP-------FMKFVAHAASFI-----IFLGL---------------------LVFNASDRFEGITTLPNI-----TVTDYPKQIFRVKTTQ-------FTWTEM-----LI-----------------------------------------------------------------------MVW--------------------------------------------VLGMMWSEC------KELWLEGPRE----------------------YILQLWNVLDFGMLSIFIAAFTARF----LAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYA--------RDKWL----PSDPQ------IISEG--------LYAIAVVLSF-------------------------------------SRIAYILPANESFGPLQI----------SLGRTVKD-IFK-------FMVLFIMVFFA---------------------------FMIGMF----------ILY-----SYYLGAKV------------------NAAFTTVEESFKTLFWSIFGLS------EVTSVVL---------------------------------KYDHKFI-ENIGYVLYGIYNVTMVVVLLNMLIAMIN----------------------SSYQEIED-------DSDVE-----------------------------------------------------W---------------KFARS-------------KLWLSYFDDGK-------------------------------------------TLP----------------------------------------------PPF-------------------------SLVPSPKSFV------------------------YFIMRI---------------------VN--------------------------FPKCRRRRLQKDIEMGMGNSKSRLNLF----------------------------TQSNSRVFESHSFN-SILNQPTRYQ-QIMKRLIKRYVLK--------AQVDKENDE---VNEGELK-EIKQDISSLRY-ELLEDKSQAT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE-LAILIHKLSEK-----------------------------------------------------------------------------------------------------LNPSM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRCE------------------------------------------------------------------------------------------- familyTRC-geneTRPC7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRNST-------F-KNMQRRHTTLREKGRRQA------------------------------------------------------------------------------------------------------IRGPAYMFN------------------------------------------------------------------------------------------------EKGTSLT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEEE----------------------------------------RFLD-------SAEYG---------------NIPVVRKM---------------------------------------------------LEES-----------------------------------------------------KTLNFNC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD-----------------------------YMGQ-------------------------------------------NALQL----------------------AVGNEH-------------------------------------------------------------LEVTELLLK---------------------------------------------------------------------------------------------KENLARVGDALLLAI---------------------SKGYVRIV---------------------------EAILNHP------------------------------AFAQGQRL--------------------------------------------------------------TLSPLEQELRDDD------------------------------------------------------------------FYAY----------------------------------------------------DEDGTRF------------------------SHDITPIILAAHCQEYE---------------------IVHILLLKGAR------------------------IERPH-----------------------------------------------------DYFCKCNECTEKQRK---------------------------DSFSH----------------------SRSRMNAYKGLASAA-------------------------------------Y-------------------------------------------------------------------------------------------------------------LSLSSEDP--------------VLTALEL------------------------SNELARLA--------------NI-ETEF--------------KND----------------YRKLSM-QCKD---FVVGV-------------------LDLCRDTE---------------------------------------------EVEAI--------------------------LNGDVN----------------------------FQVW-----------------------------------SDHHRPSLSRIKLAIKYE--------------VKKFVA--------------HPNCQQQLLTMWY-------------ENLSGL---------------------------RQQSIA----------------------VKFLAV-----------------------------FGVSI------------------GLPFLAIAYWIA---------------------------------------------------------PCSKLGRTLR-------SP-------FMKFVAHAVSFT-----IFLGL---------------------LVVNASDRFEGVKTLPNE-----TFTDYPKQIFRVKTTQ-------FSWTEM-----LI-----------------------------------------------------------------------MKW--------------------------------------------VLGMIWSEC------KEIWEEGPRE----------------------YVLHLWNLLDFGMLSIFVASFTARF----MAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYA--------RDKWW----PSDPQ------IISEG--------LYAIAVVLSF-------------------------------------SRIAYILPANESFGPLQI----------SLGRTVKD-IFK-------FMVIFIMVFVA---------------------------FMIGMF----------NLY-----SYYRGAKY------------------NPAFTTVEESFKTLFWSIFGLS------EVISVVL---------------------------------KYDHKFI-ENIGYVLYGVYNVTMVVVLLNMLIAMIN----------------------NSYQEIEE-------DADVE-----------------------------------------------------W---------------KFARA-------------KLWLSYFDEGR-------------------------------------------TLP----------------------------------------------APF-------------------------NLVPSPKSFY------------------------YLIMRI-----------------KMCLIK--------------------------LCKSKAKSCENDLEMGMLNSKFKKTRY-----------------------------QAGMRNSENLTAN-NTLSKPTRYQ-KIMKRLIKRYVLK--------AQVDRENDE---VNEGELK-EIKQDISSLRY-ELLEEKSQAT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GE-LADLIQQLSEKFGK-------------------------------------------------------------------------------------------------NLNKDH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRVNKGKD----------------------I---------------------------------------------------------------- familyTRC-geneTRPC6 -MSQS-------------------------------------------------------------------------------------------------------------------------------------------------PA------------------------------------------------------------------------------------------------------------------------------------F------------------------------------GPRR---------------------------------------------------------------------------------------------------------------------------------------------------------GSSPR-------------------------GAAG----------AAARRNESQ---------------------------------------------------DYLLMDSELGEDGCPQAPLPC------------------------------------------YGYYPCFRGSD-------N-RLAHRRQTVLREKGRRLA------------------------------------------------------------------------------------------------------NRGPAYMFS------------------------------------------------------------------------------------------------DRSTSLS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEEE----------------------------------------RFLD-------AAEYG---------------NIPVVRKM---------------------------------------------------LEEC-----------------------------------------------------HSLNVNC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD-----------------------------YMGQ-------------------------------------------NALQL----------------------AVANEH-------------------------------------------------------------LEITELLLK---------------------------------------------------------------------------------------------KENLSRVGDALLLAI---------------------SKGYVRIV---------------------------EAILSHP------------------------------AFAEGKRL--------------------------------------------------------------ATSPSQSELQQDD------------------------------------------------------------------FYAY----------------------------------------------------DEDGTRF------------------------SHDVTPIILAAHCQEYE---------------------IVHTLLRKGAR------------------------IERPH-----------------------------------------------------DYFCKCNDCNQKQKH---------------------------DSFSH----------------------SRSRINAYKGLASPA-------------------------------------Y-------------------------------------------------------------------------------------------------------------LSLSSEDP--------------VMTALEL------------------------SNELAVLA--------------NI-EKEF--------------KND----------------YKKLSM-QCKD---FVVGL-------------------LDLCRNTE---------------------------------------------EVEAI--------------------------LNGDVE------------------------T---LQS------------------------------------GDHGRPNLSRLKLAIKYE--------------VKKFVA--------------HPNCQQQLLSIWY-------------ENLSGL---------------------------RQQTMA----------------------VKFLVV-----------------------------LAVAI------------------GLPFLALIYWFA---------------------------------------------------------PCSKMGKIMR-------GP-------FMKFVAHAASFT-----IFLGL---------------------LVMNAADRFEGTKLLPNE-----TSTDNAKQLFRMKTSC-------FSWMEM-----LI-----------------------------------------------------------------------ISW--------------------------------------------VIGMIWAEC------KEIWTQGPKE----------------------YLFELWNMLDFGMLAIFAASFIARF----MAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLA--------RIKWD----PSDPQ------IISEG--------LYAIAVVLSF-------------------------------------SRIAYILPANESFGPLQI----------SLGRTVKD-IFK-------FMVIFIMVFVA---------------------------FMIGMF----------NLY-----SYYIGAKQ------------------NEAFTTVEESFKTLFWAIFGLS------EVKSVVI---------------------------------NYNHKFI-ENIGYVLYGVYNVTMVIVLLNMLIAMIN----------------------SSFQEIED-------DADVE-----------------------------------------------------W---------------KFARA-------------KLWFSYFEEGR-------------------------------------------TLP----------------------------------------------VPF-------------------------NLVPSPKSLF------------------------YLLLKL-----------------KKWISE--------------------------LFQGHKKGFQEDAEMNKINEEKKLGILGSH---------EDLSKLSLDKKQVGHNKQPSIRSSEDFHLN-SFNNPPRQYQ-KIMKRLIKRYVLQ--------AQIDKESDE---VNEGELK-EIKQDISSLRY-ELLEEKSQNT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ED-LAELIRELGEKLS---------------------------------------------------------------------------------------------------MEPNQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EETNR------------------------------------------------------------------------------------------ familyTRC-geneTRPC2 -MLMSRTDSKS---------------------------------------GKNRSGVRM-----------------------------------------------------------------------------------FKDGDFLTPA---------------------------------------------------------------------------------------------------------------------------------SGE--------------------------------------------------------------------------------------------------------------------------------------------SWDRLRLTCSQPFTRHQ---SFGLAFLRVRSSLGSLADPVV------------DPSAPGSSGLNQNSTDVLESDP----RPWLTNPSI-------RRTFFPDPQTSTK---------EISELKGMLKQ-------------------LQPG-----PLGRAARMVLSAARKAPPASVVS-------------------------------PNNSHGEPGPSRAESAEPRA-----------EEPNRKTAVGRRKRRKVQ--------------------------------------------------------------------------------------------------------EPRRSLSNSSSQ---PNR--------------------RTGRTRQ---RQHRP--------------------------------------------------QTKSDDGGV----------QAAG------------------------QCP----------------ICAGFFSIETLPQ--------------------------------HAATCG----ESPPPQPASPA-SLSSS---------------------ESVLRRHHV-----------------ALTPVPLVPK---PQPNW-----------TEIVNKKLKFP-----------------------------------PTLLR-------AIQEG---------------QLGLVQQL---------------------------------------------------LESSSDA---------------------------------------------------------S---GA----------------GPG-------------------------------------------------------------------------------------------------------------------------------------------------------------------GPL-----------------------------------------------RNVE----------------------------ESEDRS----------------------------------------WREALNL----------------------AIRLGH-------------------------------------------------------------EVITDVLLA---N----------------------------------------------------------------------------------------VKFDFRQIHEALLVAV---------------------DTNQPAVV---------------------------RRLLARL------------------------------EREKGRKVD---------------------------------------------------------------------TKSFSL----------------------------------------------------------------AFFDS----------------------------------------------------SIDGSRF------------------------APGVTPLTLACQKDLYE---------------------IAQLLMDQGHT------------------------IARPH-----------------------------------------------------PVSCACLECSNARRY---------------------------DLLKF----------------------SLSRINTYRGIASRA-------------------------------------H-------------------------------------------------------------------------------------------------------------LSLASEDA--------------MLAAFQL------------------------SRELRRLA--------------RK-EPEF--------------KPQ----------------YIALES-LCQD---YGFEL-------------------LGMCRNQS---------------------------------------------EVTAV--------------------------LNDLGED-----------------------SETEPEAEG-----------------------------LGQ-AFEEGIPNLARLRLAVNYN--------------QKQFVA--------------HPICQQVLSSIWC-------------GNLAGW---------------------------RGSTTI----------------------WKLFVA-----------------------------FLIFL------------------TMPFLCIGYWLA---------------------------------------------------------PKSQLGRLLK-------IP-------VLKFLLHSASYL-----WFL------------------------IFLLGESLVMETQLSTF---KGRSQSVWET--------------S-----------LH-----------------------------------------------------------------------MIW--------------------------------------------VTGFLWFEC------KEVWIEGLRS----------------------YLLDWWNFLDVVILSLYLASFALRLLLAGLAYMHCRDA----------------SDSTTCRYFTTA-------ERSEWR----TEDPQ------FLAEV--------LFAVTSMLSF-------------------------------------TRLAYILPAHESLGTLQI----------SIGKMIDD-MIR-------FMFILMIILTA---------------------------FLCGLN----------NIY-----VPYQESEKLG---------------------NFNETFQFLFWTMFGME-EHTVVDMPQFLV----------------------------------------PEFVGRAMYGIFTIVMVIVLLNMLIAMIT----------------------NSFQKIED-------DADVE-----------------------------------------------------W---------------KFARS-------------KLYLSYFREGL-------------------------------------------TLP----------------------------------------------VPF-------------------------NILPSPKAAF------------------------YLVRRI-----------------FRFLCC---------------------------GSSCCKAKKSDYPPIGTFTNPGARAGSA------------------------------------------GEGERVSYRLRVIKALVQRYIET----------ARREFEETRRKDLGNRLTELTKTVSRLQS-EVASVQKNLAA----------------------------------GGAPR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPDG--ASILSRYI----------------------------TRVRNSFQN------------LGPPTSDTPAELTMPGIVETEVSLGD-------------------------------------------------------------------------------------GLDGT-------------GEAGAPAPGEPGSSSSAH----------------------------VLVHREQEAEGS----------------------------------------------------------------------------------------------GDL--------------------------------------------------------------------------------------------------------------------------------------------------------------------LLEG----------------DLETKGES--------------------------------------------------------------------------------------- familyTRPP-genePK1L1 -MAEEAAQNIS---------------------------------------DDQERCLQAAC--------------------CLSFG--------GELSVSTDK-------------------------------SW-----GLHLCSCSPPG---------------------------------------------------------------------------------------------------------------------------------GGLWVEVYA-------------------NHVLLMSDGKCGCPWCAL------------------------------------------------------------------------N----------------------GKAEDRESQSPSSSASR-----QKNIWKTTSEAALSVVNEKTQAVV-------NEKTQAPL-DCDNSADRIPHKPFI-IIARAWSSGGPRFHH----RRLCATGTADSTFSALLQLQGTTSAAAPCSLKMEASCCVLRLLCCAEDVATGLLPGTVTMETPTKVARPTQTSSQRVPLWPISHF--------------------------PTSPRSSHGLPPGIPRTPSFTASQSGSEI---LYPPTQHPPVAILARNSDNFM--------------------------------------------------------------------------------------------------------NPVLNCSLEVEARAPPNLGFRVHMASGEALCLMMDFGDSSGVEMR--LHNMSEAMA------VTAYHQYSKGIFFHLLHFQLD---------------MSTYKEAETQNTTLNVY---LCQSENS--------------------------CLEDSDPSNLGYELISAFVTKGVYMLKAVIYNE-----------------------------FHGTEVELGPYYVEIGHEAVSA-FMNSSSVHEDEVLVFADS----QVNQKSTVVIHHFPSIPSYN------VSFISQTQVGDSQAW-HSMTVWYKMQSVSVYTNGTVFATDTDITF--TAVTKETIPLEFEWYFGEDPPVR--TTSRSI-KKRLSIPQWYRVMVKASNRMSSVVSEPHVIRVQKKIVANR---------------------------------------------------LTSPSSA-----------------------------------------------LVNASVAFECWINFGTD------VAY--LWDFGDGTVSLGSSSS--------------------------------------------------------------------------------------SHVYSREGEFTVEVLAFNNVSASTLRQQLFIVCEPCQPPLVKN--MGPGK------VQI------WRSQPVRL---------------G--VTFEA---------------------AVFCDISQGLSYTWN----------------LMDSEGLPVSLPA-----------------------A--------VDTHRQTLILPSH-------------------TLEYGN-------YTALAKVQIEGSVV--------YSNYCVGLEV-------------RAQAPVSVISEGTHLFFSRTTSS--------------PIVLRGTQ---------------SFDPDDPGATLR----YH-------------------------WEC-ATAGSPAHPCFDSSTAHQL-DAAAPTVSFEA--QWLSDSYDQFLVMLR----------------VSSGGRNSSETRVFLSPYPDSAFRFVHISWVSFKDTFVNWNDELSLQAMCEDCSEIP---------------------------------------------------------NLSYSWDLFLVNATEKNRIEV-------------------------------------------------------------PFCRVVGLLGSLG-----------------------------------------LGAISESSQLNLLPT---EPGTADPDATTTP--FSREPSPVTLGQPATSAPRGTPTEPMTGVYWIPPAGDSAVLGEAPEEGSLDLEPGPQSKGSLMTGRSERSQPTHSPDPHL---------------------------------------------------SDFEAYYSDIQEAIPSGGRQPAKDTSFPGSGPSLSAEESPGDGDNLVDP-------------SLSAGRAEPVLMIDWPKALLGRA-------------------------------------VFQGYSSSGITEQTVTI-----------------KPYSLS--S-----------------------------------------GETYVLQVSVAS-KHGLLGKAQLYLTVNPAPRDMACQVQPHHGLEAHTVFSVFCM-----------SGKPDFHY---EFSYQIGNTS-KH--------TLYHGRDTQYYF-----VLPAGEHLDN----------------YKVMVSTEITD--GKGSKVQPCTVV----------VTVLPRYHGND-------CLGED--------LYNS------------------SLKNLSTLQLMG------SYTEIRNYITVITR-ILSRLSKE----------------------DKTASCNQWSRI------QDALISSVCR-----------LAFVDQEEMIGSVLMLRDLVSFSNKLGFMSAVLILKYTRALLAQGQFSGPFVIDKGVRLELIGLISRVWEVSE---------QENSKEEV-------------------------YRHEEGI--TVI-----------------SDLLLG--CLSLNHVSTGQME---------F---RTLLHYNLQ-SSVQS---LGSVQVHLPGDLAGHSPAG-------------------------------------------------AETQSPCYISQLILFKKNPYPGSQAPG--QIGGVVGLNLYTCSSRRPINRQWLRKPVMVEFGEEDGLDNRRNKTTFVLLRDKVNLHQFTELSEN--PQESLQIEIEF---SKPVT-------RAFPVM-----LLVRF----------------------------------------SEKPTPSDFLV--------------KQIYFWDESIVQIYIPAASQKDASVGYLSLLDADYDRKPPNRYLAKAVNYTVHFQWIRCLFW--DKREWKSERFS-----PQPGT---------SPEKVNCSYHRLAAFALLRRKLKASFEV--SDISKLQSH------------------PENLLPSIFIMGS-VILYGFLVAKSRQVDHHEKKK-AGYIFLQEASLP--GHQLYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGR--HDGRVEREL--TCLQGGLGFRKLFYCKFTEYLEDFHVWLSVYSRPSSSRYLHTPRL----------------------TVSFSLLCVYACLTALV---AAGGQEQPHLDV-----------------SP------------------TLGSFRVGLLCTLLASPGAQLLSLLFRLSKEAPGSARV--------------EPHSPLRG-------GAQTE-------------------------------------------APHGPN---SW--------------GRIPDAQE-----PRKQPASAILSGSGRAQR----------------------------------KAASDNGTACPAPKLQVHGADHSRTSLMGKSHC-----------------------CPPHTQAPSSG----------------LEGLMPQWSRALQPWWSSAVWAICGTASLACSLGTGFLAYRFG----QEQCVQWLHLLSLSVVCCIFITQPLMVCLMALGFAWKRRADNHFFTESLCEATRDLDSELAERSWTRLPFSSSCSIPDCAGEVEKVLAARQQARHLRWAHPPSKAQL--------RGTRQRMRRESRTRAALRDISMDILMLLLLLCVIYGRFSQD----EYSLNQAIRKEFTRNAR-NCLGGLRNIAD-------------------WWDWSLTTLLDGLYPGGTPSARVPGAQPGALGGKCYLIGSSVIRQLKV--FPRHL--CKPPRPFSALIEDSIPTCSPEVG-----------------------GPENPYLIDPENQN------------------------------VTLNGPGGCGTREDCVLSL------------GRTRTEAHTALSR--------LRASMWIDRSTRAVSVHFTLYNPPTQLFTSVSLRVE-------ILPTGSLVP------------SSLVESFSI-------------FRSDSALQYHLMLPQLVFLALSLIHL--CVQLYRMMDKGVLSYWRKPRNWLELSV----VGVSLTYYA----------------------------------------VSGHLVTLAGDVTNQFHRGLCRAFMDLTLMASWNQRARW--LRGILLFLFTLKCVYLPGIQNTM--ASCSSMMRHSLPSIFVAGLVGALMLAALSHLHR-FLLSMWVLPPGTFTDAFPGLLFHFPRRSQKDCLLGLSKSDQR--------AMACYF----------------GILLIVSATLCFGMLRGFLMTL-----PQK---RKSFQSKSFVRL---KDVTAYMWEKVLT-------------------------FLRLETPKLEEAEMVE-----------------------------NHNYYLDEFANL-LDELLMKIN-GLSD---------SLQL----------------PLLEKTSNNT---------------------GEARTEESPLVDISSYQAAE-------------------------PADIKDF------------ familyTRPP-genePKD1 -MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEV-D--AAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRSLDVW-IGFSTVQGVEV-GPAPQGEAFSLESCQ-----NWLPGE--------------PHPATAEHCVRLGPTG-WCNTDLCSAPHSYVCE--------------LQPGG-PVQDAENLLVGAPSGDLQGPLTPLAQ-----QDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNRTQLA--PACMPGGRWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAPGHPGPRAPYLSANASSWL---PHLPAQLE---GTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLYVPTNGSALVLQVDSGANATATARWPGGSVSARFENVCPALVATFVPGCPWETNDTLFSVVALP-WLSEGEHVVDVVVENSASRANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSP-VVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLAL-------TAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPD--------PSVAQVLVEHNVMHTYAAPGEYLLTV-LASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDN------ITW--TFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALV----LSSRVNRAHYFTSI--CVEPEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFST------SLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEPVGW--LMVAASPNPAAVNTSVTLSAELAGGSGVVYTW------SLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQVPVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWAVP-------------------------GGSSKRG-----------PH-VTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILS----GRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGPCFTN------------RSAQFEAATSPSPR--RVAYHW--DFGDGSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVD-VVLPLQ------------VLMRRSQRNYLEAH-----------VDLRDCVTYQTEYRWEVYRTASCQRP-----------GRPARVALPG---------------VDVSRPRLVLPRLALPVGHY----CFVFVVSFGDTPLTQSIQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTI--PRERLAAG-VEYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKA-------QAVYEVSRSSYVYLEGRCLNCSSGSKRGRW---AARTFSNKTLVLDETTT-STGS---AGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEE-GCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEF--CVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQLGAAVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPG-LLRQADPQHVIEYSLALVTVLNEYERALDVAA-EPKHERQHRAQ------------IRKNITETLVSLRV---HTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTA-GTVTPTAIGDSILN--ITGDLIHLASS-DVRAPQPSELGAESPSRMVASQAYNLTSALMRILM----------RSRVLNEEPLTLAGEEIV--------------AQGKRSDPRSLLCYGGAPGPGCHFSIPE-----AFSGALANLSDVVQLIFLVDS------NP-------FPFGYISNYTVS-----TKVAS--------------------MAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNY---TLLDGHYLSEEPE--PYLAVYLHSEPRPNEHNCSASRR-IRPESLQGADHRPYTFFIS------PGS-RDPAGSYHLNLSSHFRWS---------ALQVSVGLYTSLCQYFSEEDMVWRTEGLL-----PLEET---------SPRQAVCLTRHLTAFGASLFVPPSHVRF-------VFPEPT----------------ADVNYIVMLTCAVCLVTYMVMAAILHKLDQLDASRGRAIPFCGQR-----GRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDR--AFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRIQRA----TC-----------CVLLICLFLGANAVWYGAVGDS-AYSTGHVSRLSPL--------------------------------------SVDTVAVGLVSSVVVYPVYLAILFLFRMSR--SKVA----------GSPSPTPAGQQVLD-IDSCL-DSSVLDSSFLT---FSGLHAEQAFVGQMKSDLFLDDSKSLVC------WPSG-EGTLSWPDLLSDPSIVGSNLRQLARGQAGHGLGPEEDGFSLASPYSPAKSFSASD--------------------------EDLIQQVLAEGVSSPAPTQD----THMETDLLSSLSSTPGEKT-------ETLALQRLGELGPPSPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLS---LLLVAVAVAV----SGWVGASFP----PGVSVAWLLSSSASFLASFLGWEPLKVLL------------EALYFSLVAKRLHPDEDDTLVESPAVTPVS---------------------------ARVPRVRPPHGFA---LFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHG--HAYRLQSAIKQELHSRAF-LAITRSEEL----------------------WPWMAHVLLPYVH-GNQ---------------SSPELGPPRLRQVRL---QEAL--------YPDPPGPRVHTCSAAGGF---STSDYDVGWESPH------NGSGTWAYSAPDLL---GAWSWGS--------------------CAVYDSGG------YVQEL------------GLSLEESRDRLRF--------LQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLE-------FPAAGRALA------------ALSVRPFAL--------------RRLSAGLSLPLLTSVCLLLFAVHF---AVAEARTWHRE------GRWRVLRLGAWARWLLVALTAATAL--------------------------------------VRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARG--LAASLLFLLLVKAAQQLRFVRQW--SVFGKTLCRALPELLGVTLGLVVLGVAYAQLAI-LLVSSCV---DSLWSVAQALLVLCPGT-----GLSTLCPAES-------------WHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGL--SKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRL--GTRCEPEPSRLQAVFEALLTQFDRLNQATED-VYQLEQQLH--------------SLQGRRS-------------SRAPAGSSRGPSPG------------LRPALPSRLARASRGVDLATGPSRT-------------------------PLRAKNKVHPSST------ familyTRPP-genePK1L2 -MSAVGLVLLVLALR-----------------------------------------LRA---------------------------------------------------------------------------------------TTVKPE---------------------------------------------------------------------------------------------------------------------------------EGSFCSNSQVAFR---------------DACYEF--------------------------------------------------------------------------------VPLG-------------------------RTFRDAQSWCEGQ-------GGHLVFIQDEGTQWFLQKHISQDREWW-IGLT-WNLAR--NGTTEGPGTWLDTSN-VTYSNWHGGQ------------AAAAPDTCGHIGRGPSS--EWVTSDCAQTFAFMCE--------------FRVG-------QSLACEGLNATVHCGLGQVIQV----QD--------------------AVYGRQNPHFCTQDAGRPSDLEQGCSW--------ANVKEEVAGQCQELQSCQ----------------------------------------------------------------------------------------------------------------------------------------------VAADETY-----------------------FGN--------------------------------LCPTQGSYLWVQYQ----------------------------------C-----------------------------------------------------------------------------REALQL-MVSSES-------------------------------------------FIFDNVTISL---------TWLL--------SPYIGNLSCIIS--------TGDSHTFDPYN----------------PPSVSSNV----THQFTSPGEFTVFAECTTS-EWHVTAQRQVTVRDKMETLSVTACSG---------------------------------LSQSGAGPL-----------------------CQA-------------------VFGDPLWIQVELDGGTG------VTY--TVLLGDITL---------------------------------------------------------------------------------------------AESTTQKGSL-----------------------------------------------------------PY----------------------------------------------NLILDRETQKL----------------------MGPGR-------------------------------------------HRLEIQAT-------------------GNTTTS-------------------------------TISR-----------------------NITVHLVELLSGLQAS------------------------------------------------------------------------------------W----ASDHLELGQDLLITISLAQGTP--------------EELTFEVA-----------GL--------------NATFSHE------------------------------QVSFGEPFGIC----------------------------------RL-----------------AVPVEGTF---LVTMLVRN-----------------------------------------------------------------AFSNLSLEIGNIT----------------------ITAPS----------------GLQEPSGMNAEGK---SKDKGDMEVYIQPGPYVDPFTTVTLGWPDNDKELRFQWSCGS----CWALWSSCVERQLLRT-----------------------DQRELVVPA----------------------------SCLPPPDSAVTLRL----------AVLRGQELE----------------------------------NRAEQC-------------LYVSAPWELRPRVSCERN---------------------------------------------CRPVNASKDILLRVTMGEDSPVAMFSWYLDNTPTEQAEPL-----------------------------------------LDACRLRGFWP-----------RSLTLLQSNTSTLL------------LNSSFLQ-------------------SRG-EVIRIRATA----------LTRHAYGEDTYV--------ISTVPPREVP---ACTIAPEEGTVLTSFAI-FCNA--STALGP-------------------LEFCFCLE-SGSCLHCGP--EPALPSV-YLPLG----------------EENNDFVLTVV------------------------ISATNRA----------------------GDTQQTQAMAKVA----LGDTCVEDVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSMLNQ------------EHESQGSGQSLS-----ID--VRQKVREHVLGSLSAVTTGLEDVQRV-QELAEVL---REVTCRSKELTPSAQWEA-SLALQHASEALLTVSAKARPEDQRRQAATRDLFQAVGS--VLEASLSNRP-EEPAEASSSQI----ATVLRLLRVMEHVQTTLLLGKLPGGLPAMLATPSIS--------------VYTNRIQPWS---WQG------SSLRPD-----AADSATFMLPAASSLSSLEGGQ-----EPVDIKIMSFPKSPFPARSHF--DVSGTVGG--------------------LRVTSPSGQLIPVKNLSEN--IEILLPRHSQR--HSQPTV---LN--LTSPEA-----LWVNVTSGEATLGIQLHWR-------------PD--IALTLSLGYGYHPNKSSYDAQTH-LVP---MVAPDELPTWILS------PQDLRFGEGVYYLTVVPESDLEPAPGR----DLTVGITTFLSHCVFWDEVQETWDDSGCQ-----VGPRT---------SPYQTHCLCNHLTFFGSTFLVMSNAINI--HQTAELFAT------------------FEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAK-VKVTVLEDN-DPF-AQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINV--GDCVLDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRV----SC-----------CFSLLLCTMLTSIMFWGVPKDP---AEQKMDLGKIEF-------------------------------------TWQEVMIGLESSILMFPINLLIVQIFQNTR--PRVAKEQNTGKWDRGSPNLTPSPQPMED--GLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDSVNLM--DINSLLALVEDVIYPQNTSGQVFWEE-----------AKKREDPVTL----------TLGSSEMKEKSQCPKPKA--ARSGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFSQP----------HSHAQALRQLQTLKG-----------GLGVQP-GTWAPA-------HASALQVSK-------PPQGLPWWCILVG-------WLLVAATSGV----AAFFTMLYGLHYGRASSLRWLISMAVSFVESMFVTQPLKVLGFAAFFA--------------LVLKRVDDEEDTVAPLPGHLLG----------PDPYALFRARRNSSRDVYQPPLTAAI--------EKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPS----AYHLNRHLQHSFTRGFS-GVLGFRE-----------------------FFKWANTTLVSNLY-G--------HPPGFITDGNSKLVGSAQIRQVRV---QESS------CPLAQQPQAYLNGCRAPYSLDAEDMADYGEGWNAT--------TLSEWQYQSQDQRQ--GYPIWGK--------------------LTVYRGGG------YVVPL------------GTDRQSTSRILRY--------LFDNTWLDALTRAVFVESTVYNANVNLFCIVTLTLE-------TSALGTFFTHAALQ-------SLRLYPFTD----GWH--------------PFVVAAELIYFLFLLYY---MVVQGKRMSKETWGYFCSKWNLLELAI----ILASWSALAVF----------------------------------------VKRAVLAERDLQRCRNHR-EEGISFSETAAADAALGY--IIAFLVLLSTVKLWHLLRLNPKM--NMITAALRRAWGDISGFMIVILTMLLAYSIASN-LIFGWKLRSYKTLFDAAETMVSL---------QLGIFNYEEV-------------LDYSPVL----------GSFLIGSCIVFMTFVVL-----------------NLFISVILV--------------------------------------------------AFSEEQKYY---------------------------------QLSEEGEI-VDLLLMKIL--------------SFLG------IKSK-------REEPGSSRE-QPG--------------SLSQTRHSRPAQAL----------------------------------PKD---------------- familyTRPP-genePK1L3 -MFFKGGSWLWLYIR-------------------------------------TSIILGS---------------------------------------------------------------------------------------ELNSPA--------------------------------------------------------------------------------------------------------------------------------PHGQ-------------------------NNCYQL-N----------RF----------------------------------------------------------------------------------------------QCSFEEAQHYCHVQ-------RGFLAHIWNKEVQDLIRDYLEEGKKWW-IGQNVMPLKK--HQDNKYPADVAAN-----------GP--------------PKPLSCTYLSR-NFIRISSKGDKCLLKYYFICQ-------------------------------------------------------------------------------TGDFLDGDAHYE-----------------RNGNNSHLYQRHKKTKRG----------------------------------------------------------------------------------------------------------------------------------------------VAIARDK-----MPPGPG-----------------------------------------------HLPTT-------------------------------------------C-----------------------------------------------------------------------------HYPLPA-HLSKT------------------------------------------------------------------------------------LCH-----------------PISQF-------------PSVLS-----------------------------SITSQV---------------------------------------------------TSAASEPSS------------------------------------------------QPLPVI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQLTMPV--------------------SVTHAG-------------------------------------------------------------QSLAETTSS----------------------------------------------------------------------------------------------PKEEGHPNTFTSYL--------------------------------------------------------QVSL---------------------------------QKASGQVID---------------------------------------------------------EIAGNFSRAVHGLQALN-------------------------------------------------------------------------------------------------------------------------KLQEACEF------------------------LQKLTALTPRFSKPAQV--------------------NLINSLIYL-----------------------SEELLRIPF----QNN----------------------------------------------------------------------------------------NSL----------------------------------------------------------------------------------------------------------GFKVPP------------------------------------------------------------------------------------------------TVCPFHS---------------------------LNNVT--------------KAGEGSW-----------------------------------------------------------------------LESKRHTE----------------------PV--------------------EDILEMS-------------------------LVEFGNI----------------------------------------GEAF-----------------LEQNQSPESSVTLTSANATLLLS----------------------------------RQNISTLPLSSYTL------------GHPAP--------------------------------------------------------VRLGFP-----------------------------SALAL-------------KELLNKHPGV-------------------------------------------N----------------------VQITGLAF-------NP-------FKDL--DNRNIV-----GSIGS---------------------VLLSANRKLLQVHDLMED--IEIMLWRNVSL--ETHPT---SLN--MSTHQL----TITVN---------------VTSLEKSLIVSIDPDSPLLMTLYLGFQYQPNCTHFHLN--ITLPKDKVWQKDEEYTWVLN------PEHLQHGIGTYYITAVLSERQEGAQQT----PSLVSVITAVTQCYYWEIHNQTWSSAGCQ-----VGPQS---------TILRTQCLCNHLTFFASDFFVVPRTVNV--EDTIKLFLR------------------VTNNPVGVSLLASLLGFYVITVVWARKKDQADMQK-VKVTVLADN-DPS-AQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDL--GDCELDRVFIPVSKRELFSFRHLFSSMIVEKFTQDYLWLSIATRHPWNQFTRVQRL----SC-----------CMTLLLCNMVINVMFWKINST-----------TAKR----------DEQMR----PFA--V-------------AWSELLVSIHTAVILFPINLVIGRLFPLIE--PQETL---------------PLFPPIQA---SCLSDASVEPLSATM--VVEELK--------ETVRFLLRRNTYLLSKCEQPPWSS-------W-D-----------ITKLVKLLS-----------SLVSSHLEGQGCHQQGERHWARVVP--ENHHHFCCYLHRVL-QRLKSHLGTLGLTQG----------HQSCDFLDAASQLQKLQ--------ELLETHI----LPTEQEPSREVTSFAILSSEEGKKP-ISNGLSKWLTSVC-------WLLLGFTSLA----SAFFTALYSLELSKDQATSWMISIILSVLQNIFISQPVKVVFFTFL--------YSLMMSRMPRLNKENE------QQTKRILALL------AK-CSSSVPGSRDKNNPVYVAPAINSPT---------KHPERTLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSN----RFYLHQAIWKTF-SHQF-SEIKLLQDF----------------------YPWANHILLPSLY-GDY------RGKNAVLEPSHCKCGVQLIFQI---------------------PRTKT--------------------------------------YEKVD---------EGQ--------------------LAFCDNG-----------------------------HTCGRPKS--------LFPGLHLRRFSYICSPRPMVLIPTDELHERLTSKNENGF---SYIMRGAFFT------------SLRLESFTS-------------LQMSKKGCVWSIISQVIYYLLVCYY---AFIQGCQLKQQKWRFFTGKRNILDTSI----ILISFILLGLD----------------------------------------MKSISLHKKNMARYRDDQ-DRFISFYEAVKVNSAATH--LVGFPVLLATVQLWNLLRHSPRL--RVISRTLSRAWDEVVGFLLIILILLTGYAIAFN-LLFGCSISDYRTFFSSAVTVVGL---------LMGISHQEEV-------------FALDPVL----------GTFLILTSVILMVLVVI-----------------NLFVSAILM--------------------------------------------------AFGKERKS-----------------------------------LKKEAAL-IDTLLQKLS--------------NLLG----------------ISWPQKTSSE------------------QAATTAVGSDTEVLDEL-------------------------------P------------------ familyTRPP-genePKDREJ -MRPGPALLLL----------------------------------------GVGLSLSV--------------------------G------------------------------------------------------------RLPLPP-------------------------------------------------------------------------------------------------------------------------------VPRGAQAAV-------------------------------SGAPGGLL--------------------------------------------------------RGAPG---------LG------------------------VRGGRALLSLRPSAVR----AGGAV--LSGRGSLCFPHGGTG--RRWYCLDLRVLLSAQR-LPWPAAPALALVDLQL---------------------SARGGRLSLTWSVRLPRS----------------------------------PG----RLAWAFRLRLLGPGAARPASPAAR-------------------------------VSPRSAAPGPRPQQGFVARTEC-------PTDGPARVMLQAVNSSSHRAV-------------------------------------------------------------------------------------------------------ESSVSCQ-------------------------------INACVIQ----------------RVRINTDQKGAPVRLSMQ------------------------AEATINASVQLD------------------------------------CPA---------------------------------------------------------------------------ARAIAQ-------------------Y--WQVF---------------------------SVPAVGQAPD-------WTQPLDL---PQLEIRNSPLFIHIPNNSLQWGVYVFNFTVSIT--------TGNPKM-PEVKDSDAVYVWIVRSSLQAVMLGDA----NITANFTEQL--------------------------------------------------ILDGSTSSDP------------------------DADSP----------------LQGLQFFWYCTTDPRNYG--------------GDRIILGSKEVCH-----------------------------------------------------------------------------------------PEQANLK------------------------------------------------W----PWASGPV---------------------------------------------LTLLPE----------------------------TLKGD------HV-------------------YF--------------FRMVIRKDSRT----------------AFSDKR-----VHVLQGPKAIAHITCI---------ENCERNF---------------IVSDRFSLFLNCTNCASRDFYK------------------------------------------------------------------------------------WSILSSSGGEMLFDWMGETVTGRNGAYLSIKA-FAFRHFLEAEFSISLY--------------LACWSGVTSVFRHSFIINHGPQIGECKINPAKGIA-----------LITKFVVQCSNFR-------------------------------------------------------DKHVPLTYKIIVSDLHSVG--EIS---SVKENTLGTILYLGPQSTVP------------------------------------PSFLPVGML------------------------------------------------ASQYGLKIYAQVY-----------------DSLGAFSQVTLHATAQAPT--------------DKNSSKTVLNQLLSFTVGPSS------------LLSTLIQKKDFLPA----GYL---------------------------------------------LYIVASVL-----------------------------------NNMKT------------------ELPLRDDRVNLRKHLIDQSF------------------------------------LLPVSTLVEIGQVVMTI------------TKLTQKPSEFTWDA-----------------------------------------QKRATMR-VWQA-NQALQEYQQKDKRFRSEQIEI--------------VSTGILM----------------------SLSNILKMTS------------PHQVVKDPFY---------VIESLSDTI---LANKVP--GNKTTSMRTPNFNM---YVKKVEK------------WG---INQLFRNE-----KHCRN---------CFYPT--------------------LNVSSVPG------------------------LSANGPI-----------------------STMFCDFTNDL-----------------------FPW-LN--DQENTSVEVSGFRMTGVADNG--------SVLEITPDVAEVYL---------VRKNLTFAAFNLTVGPNSEVD------GSLKKTTG---------------------GFSFQVDSTVLREVL-----------------VHIVTEVMVLFTVLVYTG---------SQI-----TPTALVA----------TFLVPHDIPPFASQSALF---------------------------------------DPA----CTVKKARVVCLPVSLLQLIAQHSH----SPHC-----TVSIVLQAPRFV-----MKLND---------------------KLVRISIFSVQCLDMYGI---------QSEW----REGYC-----------------IL--------------------------------------------------------------------GEKTSW-------------------------------------------YEVHCICKNVV--RARRQLGT------I--------------------GLTGIHLHTHYVMAKVIVIPNPVDLRLNIIKSLH----------------------QNPVTLFTVLFIILLYVGLAFWALYRDEMDQHLRGHVIVLPDN-DPY-DNLCYLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLSV-----DTTLDRTFHVTHPDERLTRKDFFFIDVSSNLRKNHMWFSIFASVVAKTFNRLQRL----SC-----------CLAMLLSSLLCNIMFFNLNRQE------QTESRERK--------------------------------------YMRSMMIGIESVLITIPVQLLITFLFTCSQRKPQ------------------ADLKEVSPQKHPLMSEASEH-----------------------------------------------------WEE----------YLRKWHAYETAK-VHPR----EVAKPASKGKPRLPK---------------------------------ASPKATSKP---------KHRHRKAQIKTPETLGPNTNSNNNIEDDQDVHS--EQHPS-------QKDLQQLKKK------PRIVLPWWCVYVA-------WFLVFATSSI----SSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVLLVQPSKIIL------------LSGFRTNKPKYCKNLSWSTKYKYTEIRLDG------------MRMHPEEMQRIHDQIVRIRGTRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIVLLRHTD----CFYYNQFIRDRFSMDLA--TVTKLEDI----------------------YRWLNSVLLPLLH-ND-------LNPTFLPESSSKILGLPLMRQVRAK-SSEKM--CLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAID-ESTNGFTYKPQGTQ--WLYYSYGL--------------------LHTYGSGG------YALYFFP----------EQQRFNSTLRLKE--------LQESNWLDEKTWAVVLELTTFNPDINLFCSISVIFE-------VSQLGVVNT------------SISLHSFSL-----------ADFDRKASAEIYLYVAILIFFLAYVVD------EGCIIMQERASYVRSVYNLLNFALK--CIFTVLIVLFLRK----------------------------------H---------FLATGIIRFYLSNPEDFIPFHAVSQVDHIMRI--ILGFLLFLTILKTLRYSRFFYDV--RLAQRAIQAALPGICHMAFVVSVYFFVYMAFGY-LVFGQHEWNYSNLIHSTQTVFSY---------CVSAFQNTE--------------FSNNRIL----------GVLFLSSFMLVMICVLI-----------------NLFQAVIL-------SAYEEMKQPV------------------------------YEEPSDEVEAMTYLCRKL-----------------------RTMFSFLTSQSKA-KDEPEFFID--------------MLYG-----------------QPEKNSHRY------------------LGLKTRNINGKKMVYLVV------------------------------------------------- familyTRM-geneTRPM1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MK--DSNRC---------------------------------C-CGQFTNQHIPPLPSATPSKNEEESKQV--------------------------------ETQPEKWSVAKHTQSYPTDS-------------------------------YGVLEFQGGGYSNKAMYIRVSY---------DTKPDSLLHLMVKDWQLE--------------------------------------------------------------------------------------------------------LPKLLIS-------------------------------VHGGLQN---FEMQP----------KLKQVFGKGLIK----------------------------AAMTTGAWI---------------------------------------------------------FTGGV-------------------------------------------------------STGVIS-HVGDA------------------------LKDHSSKSRG-------------RVCAIGIAP--------W-----------GIVENKEDLVG--------KDVTRVYQTMS---------NPLSKL--SVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQK---------------------------------------------------INTR---------------------------------------------------LGQGVPLVGLVVEG-----------------GPNVVSIVLEYL------------------------------------------------------------------------------------------QEEPPI-----------------------------------------------------------PV-----------------------------------------------VICD-----------------------------GSGRASDILS----------------------F--------------AHKYCEEG-------------------GIINES-------LREQLLVTIQKTF-----------NYNK-------------------AQSHQLFAIIMECMKKKEL-----------------------------------------------VTV-----------------------------------F-RMGSEGQQDIEMAILTAL--LKGTNVSAP----------DQLSLALA-------------------------WNRVDIARS-----------------------------QIFVFGPHWPPLGSLAPPTDSKATEKEKKPPMATTKGGRGKGKGKKKGKVKEEVEEETDPRKIEL-LNWVNALEQAMLDALVLD--RV-------------------------------------------------------------DFVKL---------------------------------------------------LIENGVNM------------------------QHFLTIPRLEELYNTRL----------------GPPNT-LHLLVR------------------------DVKKSNLPP----DYH-----------------------ISLIDIGLVL------------EYLMGGAYRCNYTRKN-FRTLY---------------------NNL------------------------FGPKRPKALKLLG-----------MEDDEPPAKGK-------------------KKKKKKKEEEIDIDVDDP--------AVSRFQYPFH--------------------------------------------------ELM-VWA----VLMKRQKMAVFLWQRGEES--------------MAKALVA--------------CKL----------YKAMA-------------HESSESDL----------VDDISQD----------------LDNNSK-DFGQ---LALEL-------------------LDQSYKHD--------------------------------------------EQIAMK--------------------------LLTYEL---------------------------------------------------------------------KNWSNSTCLKLAVAAK--------------HRDFIA--------------HTCSQMLLTDMWM-------------GRLR-----------------------------MRKNPG----------------------LKVIMG--ILLPP----------------------TILFL------------EFRTYDDFSYQTS---------KENED-----GKEKEEENTDANADAG--------SRKGDEE--NEHKKQRSIPIGTKICEFYN-------AP-------IVKFWFYTISYL-----GYL------------------------LLFNYVILVRMDGW----------PSLQEW--------------------------IV-----------------------------------------------------------------------ISY--------------------------------------------IVSLALEKI------REILMSEPGK------------LSQKIKV---WLQEYWNITDLVAISTFMIGAILRL-------------------------------------------------Q----------NQP------YMGYG------RVIYCVDIIFWY-------------------------------------IRVLDIFGVNKYLGPYVM----------MIGKMMID-MLY-------FVVIMLVVLMS---------------------------FGVARQ----------AIL-------HPEEKPS--------------------WKLARNIFYMPYWMIYGEV---FADQIDLYAMEINPPCGENLYDEEGK--RLP-----PCI----------PGAWLTPALMACYLLVANILLVNLLIAVFN----------------------NTFFEVKS-------ISNQV-----------------------------------------------------W---------------KFQRY-------------QLIMTFHDR-----------------------------------------------------------------------------------------------PV---------------------------LPPPMIILS-----------------------HIYIII-----------------MRLSGRCRK-K---------------REGDQEERDRGLKLFLSDEELKRLHEFEEQCVQ------------EHFREKEDEQQSSSDERIRVTSERVENM---SMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNALENLA---GID--RSDLIQARSRAS-SEC-E------------------------------ATYLLR-------------QSSINSADGYSLYR-----YHFN---GEELL---FEDTSLSTSPGTGVRKKTCSF-----------------------------RIKEEKDVKT-HLV---------------------------------------------------PE---CQNSLHLS-------------------LGTSTSA-------------------------------TPDGS----------------------------------------------HLAVDDLKNA---------------------------EESKLGPDI---GISKEDDERQTD--------------------------------------SKKEETISPSLNKTDVIHGQDKSDVQNTQLTVETTN-----------------------IEGTISYP-LEETKITRYFPDET-------------------INACKTMKSRSF-----------------------------------------------VYS--------RGRKLVGGVNQDV---EYS----------------SITDQ----QLT---TEWQCQVQKITR-------------------------SHSTDIPYIVSE------------------AAVQAEHKEQFADMQDEHHVAEAIPRI--PRLSLTIT--------------DRNG------MENLLSV----KPDQTLGFPSLRSKSLHG----------HPRNVKSIQGKL-DRSGHASSVSSL-----VIVSGMTAEE---------KKVKKEKASTETEC--- familyTRM-geneTRPM3 -MPEPWGTVYF-------------------------------------------LGIAQ--------------------------------------------V-------FSFLF------------------SWWNLEGVMNQADAPRPLNWT--------------------------------------------------------------------------------------------------------------------------------------------------------IRKLCHAA-----FLPSV---------------------------------------------------------------------------------------------------RLLKAQKSWIERA-------------FYKRECVHII------------------PSTK--DPHRC---------------------------------C-CGRLIGQHVGLTPSISVLQNEKNESRL-----------------------------SRNDIQSEKWSISKHTQLSPTDA-------------------------------FGTIEFQGGGHSNKAMYVRVSF---------DTKPDLLLHLMTKEWQLE--------------------------------------------------------------------------------------------------------LPKLLIS-------------------------------VHGGLQN---FELQP----------KLKQVFGKGLIK----------------------------AAMTTGAWI---------------------------------------------------------FTGGV-------------------------------------------------------NTGVIR-HVGDA------------------------LKDHASKSRG-------------KICTIGIAP--------W-----------GIVENQEDLIG--------RDVVRPYQTMS---------NPMSKL--TVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQK---------------------------------------------------INTRCLPFFS-LDSRLFYSF---------WGSCQLDSV----------------GIGQGVPVVALIVEG-----------------GPNVISIVLEYL------------------------------------------------------------------------------------------RDTPPV-----------------------------------------------------------PV-----------------------------------------------VVCD-----------------------------GSGRASDILA----------------------F--------------GHKYSEEG-------------------GLINES-------LRDQLLVTIQKTF-----------TYTR-------------------TQAQHLFIILMECMKKKEL-----------------------------------------------ITV-----------------------------------F-RMGSEGHQDIDLAILTAL--LKGANASAP----------DQLSLALA-------------------------WNRVDIARS-----------------------------QIFIYGQQWP-----------------------------------------------------------VGSLEQAMLDALVLD--RV-------------------------------------------------------------DFVKL---------------------------------------------------LIENGVSM------------------------HRFLTISRLEELYNTRH----------------GPSNT-LYHLVR------------------------DVKKGNLPP----DYR-----------------------ISLIDIGLVI------------EYLMGGAYRCNYTRKR-FRTLY---------------------HNL------------------------FGPKRPKALKLLG-----------MEDDIPLRRGRKT--------------------TKKREEEVDIDLDDP--------EINHFPFPFH--------------------------------------------------ELM-VWA----VLMKRQKMALFFWQHGEEA--------------MAKALVA--------------CKL----------CKAMA-------------HEASENDM----------VDDISQE----------------LNHNSR-DFGQ---LAVEL-------------------LDQSYKQD--------------------------------------------EQLAMK--------------------------LLTYEL---------------------------------------------------------------------KNWSNATCLQLAVAAK--------------HRDFIA--------------HTCSQMLLTDMWM-------------GRLR-----------------------------MRKNSG----------------------LKVILG--ILLPP----------------------SILSL------------EFKNKDDMPYMSQAQEIH-LQEKEAEE-PEKPTKEKEEEDMELTAMLGR--NNGESSRKKDEE--EVQSKHRLIPLGRKIYEFYN-------AP-------IVKFWFYTLAYI-----GYL------------------------MLFNYIVLVKMERW----------PSTQEW--------------------------IV-----------------------------------------------------------------------ISY--------------------------------------------IFTLGIEKM------REILMSEPGK------------LLQKVKV---WLQEYWNVTDLIAILLFSVGMILRL-------------------------------------------------Q----------DQP------FRSDG------RVIYCVNIIYWY-------------------------------------IRLLDIFGVNKYLGPYVM----------MIGKMMID-MMY-------FVIIMLVVLMS---------------------------FGVARQ----------AIL-------FPNEEPS--------------------WKLAKNIFYMPYWMIYGEV---FADQID-------PPCGQNETREDGKIIQLP-----PCK----------TGAWIVPAIMACYLLVANILLVNLLIAVFN----------------------NTFFEVKS-------ISNQV-----------------------------------------------------W---------------KFQRY-------------QLIMTFHER-----------------------------------------------------------------------------------------------PV---------------------------LPPPLIIFS-----------------------HMTMIF-----------------QHLCCRWRK-----------------HESDPDERDYGLKLFITDDELKKVHDFEEQCIE------------EYFREKDDRFNSSNDERIRVTSERVENM---SMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLT---GLE--RAESNKIRSRTS-SDCTD------------------------------AAYIVR-------------QSSFNSQEGNTFKL-------------QESIDPAGEETMSPTSPTLMPRMRSHSFY--------------------------SVNMKDKGGIEKLESIF--------------------------------------------------KE---RSLSLHRA-------------------TSSHSVAK-EPKAPAAPANTL---------------AIVPDSR----------------RPSSCIDI--------------YVSAMDELHCDIDPLDNSVNILGL---------------------GEPSFSTPVP--STAPSSSAYATL--------------------------------------APTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWD--------------------SEPPM-YHTIERSKSSRYLATTPF-----------------LLEEAPIVKSHSF-----------------------------------------------MFS--------PSRSYYANFGVPVKTAEYT----------------SITDC----------IDTRCVNAPQAI-------------------------ADRAAFPGGLGDKVEDL-------------TCCHPEREAELSHPSSDSEENEAKG----RRATIAIS--------------SQEGDNSERTLSNNITVP---KIERANSYSAEEPSAPYA----------HTRKSFSISDKL-DRQRNTASLRNP-----FQRSKSSKPEGRGDSL-SMRRLSRTSAFQSFESKHN familyTRM-geneTRPM6 -MKEQ-------------------------------------------------------------------------------------------------------------------------------------------------PV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LERLQSQKSWIKGV-------------FDKRECSTII------------------PSSK--NPHRCTPVCQVCQNLI---------------------RCYCGRLIGDHAGIDYSWTISAAKGKES--------------------------------------EQWSVEKHTTKSPTDT-------------------------------FGTINFQDGEHTHHAKYIRTSY---------DTKLDHLLHLMLKEWKME--------------------------------------------------------------------------------------------------------LPKLVIS-------------------------------VHGGIQN---FTMPS----------KFKEIFSQGLVK----------------------------AAETTGAWI---------------------------------------------------------ITEGI-------------------------------------------------------NTGVSK-HVGDA------------------------LKSHSSHSLR-------------KIWTVGIPP--------W-----------GVIENQRDLIG--------KDVVCLYQTLD---------NPLSKL--TTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQK---------------------------------------------------IHCRS-------------------------------------------------R--QGVPVVGLVVEG-----------------GPNVILSVWETV------------------------------------------------------------------------------------------KDKD-------------------------------------------------------------PV-----------------------------------------------VVCE-----------------------------GTGRAADLLA----------------------F--------------THKHLADE-------------------GMLRPQ-------VKEEIICMIQNTF-----------NFSL-------------------KQSKHLFQILMECMVHRDC-----------------------------------------------ITI-----------------------------------F-DADSEEQQDLDLAILTAL--LKGTNLSAS----------EQLNLAMA-------------------------WDRVDIAKK-----------------------------HILIYEQHWK-----------------------------------------------------------PDALEQAMSDALVMD--RV-------------------------------------------------------------DFVKL---------------------------------------------------LIEYGVNL------------------------HRFLTIPRLEELYNTKQ----------------GPTNTLLHHLVQ------------------------DVKQHTLLS----GYR-----------------------ITLIDIGLVV------------EYLIGRAYRSNYTRKH-FRALY---------------------NNLYR--------------KYKHQRHSSGNRNESAESTLHSQ--------FIRTAQPYKFKEKS---------------IVLHKSRKKSKEQNVS-DDP--------ESTGFLYPYN--------------------------------------------------DLL-VWA----VLMKRQKMAMFFWQHGEEA--------------TVKAVIA--------------CIL----------YRAMA-------------HEAKESHM----------VDDASEE----------------LKNYSK-QFGQ---LALDL-------------------LEKAFKQN--------------------------------------------ERMAMT--------------------------LLTYEL---------------------------------------------------------------------RNWSNSTCLKLAVSGG--------------LRPFVS--------------HTCTQMLLTDMWM-------------GRLK-----------------------------MRKNSW----------------------LKIIIS--IILPP----------------------TILTL------------EFKSKAEMSHVPQSQDFQFMWYYSDQN-ASSSKESASVKEYDLERGHD--------EKLDENQHFGLESGHQHLPWTRKVYEFYS-------AP-------IVKFWFYTMAYL-----AFL------------------------MLFTYTVLVEMQPQ----------PSVQEW--------------------------LV-----------------------------------------------------------------------SIY--------------------------------------------IFTNAIEVV------REICISEPGK------------FTQKVKV---WISEYWNLTETVAIGLFSAGFVLRW------------------------------------------------G-----------DPP------FHTAG------RLIYCIDIIFWF-------------------------------------SRLLDFFAVNQHAGPYVT----------MIAKMTAN-MFY-------IVIIMAIVLLS---------------------------FGVARK----------AIL-------SPKEPPS--------------------WSLARDIVFEPYWMIYGEV---YAGEIDVCS-------------------SQP-----SCP----------PGSFLTPFLQAVYLFVQYIIMVNLLIAFFN----------------------NVYLDMES-------ISNNL-----------------------------------------------------W---------------KYNRY-------------RYIMTYHEK-----------------------------------------------------------------------------------------------PW---------------------------LPPPLILLS-----------------------HVGLLL-----------------RRLCCHRAPH-------------------DQEEGDVGLKLYLSKEDLKKLHDFEEQCVE------------KYFHEKMEDVNCSCEERIRVTSERVTEM---YFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVLS---AVDTLQEDEALLAKRKH-STCKKLPHSWSNVICAEVLGSMEIAGEKKYQYYSMPSSLLRSLA-GG-------RHPPRVQRGALLEITNSKREATNVRNDQERQETQSSIVVSGVSPNRQAHSKYGQFLLVPSNLKR--VPFSAETVLPLSRPSVPDVLATEQDIQTEVLVHLTGQTPVVSDWASVDEPKEKHEPIAHLLDGQD------KAEQVLPTLSCTPEPMTMSSPLSQAKIMQTGGGYVNWAFSEGDETGVFSIK--KKWQTCLPSTCDSDSSRSEQHQKQAQDSSLSDNSTRSAQSSECSEVGPWLQPNTSFWINPLRRYRPFARSHSFRFHKEEKLMKICKIKNLSGSSEIGQGAWVKAKMLTKDRR-LSKKKKNTQGLQV---PIITVNACSQSDQLNPEPGENSISEEEYSKNWFTVSKFSHTGVEPYIHQKMKTKEIGQCAIQISDYLKQSQEDLSKNSLWNSRSTNLNRNSLLKSSIGVDKISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQL--FAGEEITVYRLEESSPLNLDKSMSSWSQRGRAA---------MIQVLSREEMDGGLRKAMRVVSTWSEDDILK--------PGQVFIVKSFLPEVVRTWH----------------KIFQESTVLHLCLREIQQQRAAQKLIY-------------------------TFNQVKPQTIPYTPRFLEVFLIYCHSANQWLTIEKYMTGEFRKYNNNNGDEITPTNT-LEELMLAFSHWTYEYTRGELLVLDLQG------VGENLTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCRKLKLPDLKRNDYSPERINSTFGLEIKIESAEEP------PARETGRNSPEDDMQL--- familyTRM-geneTRPM7 -M------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQKSWIEST-------------LTKRECVYII------------------PSSK--DPHRCLPGCQICQQLV---------------------RCFCGRLVKQHACFTASLAMKYSDVKLGDHF-------------------------------NQAIEEWSVEKHTEQSPTDA-------------------------------YGVINFQGGSHSYRAKYVRLSY---------DTKPEVILQLLLKEWQME--------------------------------------------------------------------------------------------------------LPKLVIS-------------------------------VHGGMQK---FELHP----------RIKQLLGKGLIK----------------------------AAVTTGAWI---------------------------------------------------------LTGGV-------------------------------------------------------NTGVAK-HVGDA------------------------LKEHASRSSR-------------KICTIGIAP--------W-----------GVIENRNDLVG--------RDVVAPYQTLL---------NPLSKL--NVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQR---------------------------------------------------IHAR---------------------------------------------------IGQGVPVVALIFEG-----------------GPNVILTVLEYL------------------------------------------------------------------------------------------QESPPV-----------------------------------------------------------PV-----------------------------------------------VVCE-----------------------------GTGRAADLLA----------------------Y--------------IHKQTEEG-------------------GNLPDA-------AEPDIISTIKKTF-----------NFGQ-------------------NEALHLFQTLMECMKRKEL-----------------------------------------------ITV-----------------------------------F-HIGSDEHQDIDVAILTAL--LKGTNASAF----------DQLILTLA-------------------------WDRVDIAKN-----------------------------HVFVYGQQWL-----------------------------------------------------------VGSLEQAMLDALVMD--RV-------------------------------------------------------------AFVKL---------------------------------------------------LIENGVSM------------------------HKFLTIPRLEELYNTKQ----------------GPTNPMLFHLVR------------------------DVKQGNLPP----GYK-----------------------ITLIDIGLVI------------EYLMGGTYRCTYTRKR-FRLIY---------------------NSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNH--------FIKTAQPYRPKIDT---------------VMEEGKKKRTKDEIVDIDDP--------ETKRFPYPLN--------------------------------------------------ELL-IWA----CLMKRQVMARFLWQHGEES--------------MAKALVA--------------CKI----------YRSMA-------------YEAKQSDL----------VDDTSEE----------------LKQYSN-DFGQ---LAVEL-------------------LEQSFRQD--------------------------------------------ETMAMK--------------------------LLTYEL---------------------------------------------------------------------KNWSNSTCLKLAVSSR--------------LRPFVA--------------HTCTQMLLSDMWM-------------GRLN-----------------------------MRKNSW----------------------YKVILS--ILVPP----------------------AILLL------------EYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILD--------SNEGKNE-MEIQMKSKKLPITRKFYAFYH-------AP-------IVKFWFNTLAYL-----GFL------------------------MLYTFVVLVQMEQL----------PSVQEW--------------------------IV-----------------------------------------------------------------------IAY--------------------------------------------IFTYAIEKV------REIFMSEAGK------------VNQKIKV---WFSDYFNISDTIAIISFFIGFGLRF-------------------------------------------------GAKWNFAN-AYDNH------VFVAG------RLIYCLNIIFWY-------------------------------------VRLLDFLAVNQQAGPYVM----------MIGKMVAN-MFY-------IVVIMALVLLS---------------------------FGVPRK----------AIL-------YPHEAPS--------------------WTLAKDIVFHPYWMIFGEV---YAYEIDVCANDS----------------VIPQ----ICG----------PGTWLTPFLQAVYLFVQYIIMVNLLIAFFN----------------------NVYLQVKA-------ISNIV-----------------------------------------------------W---------------KYQRY-------------HFIMAYHEK-----------------------------------------------------------------------------------------------PV---------------------------LPPPLIILS-----------------------HIVSLF-----------------CCICKRRKK----------------------DKTSDGPKLFLTEEDQKKLHDFEEQCVE------------MYFNEKDDKFHSGSEERIRVTFERVEQM---CIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTL---------TAQKASEASKVH-NEITR--------------------------ELSISKHLAQNLIDDGPV-----RPSVWKKHGVVN-------------------------TLSSSLPQGDLESNN---------------PFHC-----------NILMKDDKDPQCNIF----GQ-----DLPAVPQRKEFNFPEAGSSSGA-----------LFPSAVSPPE---LRQRLHGVELLKI--------FNKNQKLGSSSTSI-PHLSS--PPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATE--------GDNTEFGA--------------FVGHRD--SMDLQRFKETSNKIKI----------LSNNN-----TSENTLKRVS---SLAGFTDCHRTSI------------PVHSKQAEKISRRPST---------EDTHEVDSKAALIPDWLQ----DRPSNREMPSEEGTLNG------------LTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPP---RGEPVTVYRLEESSPNILNNSMSSWSQLGLCA---------KIEFLSKEEMGGGLRRAVKVQCTWSEHDILK--------SGHLYIIKSFLPEVVNTWS----------------SIYKEDTVLHLCLREIQQQRAAQKLTF-------------------------AFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNT-LEEIMLAFSHWTYEYTRGELLVLDLQG------VGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKI---------IFPQDEPSDLNLQPGNSTKESESTNSVRLML- familyTRM-geneTRPM2 -MEPSALRKAGSEQEEGFE--GLP------------------------RR-VTDLGMVS------------------------------------NLRRSNSS-----------LF-----------------KSW----------RLQCPF---------------------------------------------------------------------------------------------------------------------------------GNN--------------------------------------------------------------------------------------------------------------------------------------------DKQESLSSWIPEN-------------IKKKECVYFV------------------ESSKLSDAGKVV--------------------------------CQCGYTHEQHLEEAT-------------------------------------------KPHTFQGTQWDPKKHVQEMPTDA-------------------------------FGDIVFTGLSQK-VKKYVRVSQ---------DTPSSVIYHLMTQHWGLD--------------------------------------------------------------------------------------------------------VPNLLIS-------------------------------VTGGAKN---FNMKP----------RLKSIFRRGLVK----------------------------VAQTTGAWI---------------------------------------------------------ITGGS-------------------------------------------------------HTGVMK-QVGEA------------------------VRDFSLSSSYKEG----------ELITIGVAT--------W-----------GTVHRREGLIH------PTGSFPAEYILDE---------DGQGNL--TCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQT---------------------------------------------------KERG--------------------------------------------------GVAIKIPIVCVVLEG-----------------GPGTLHTIDNAT------------------------------------------------------------------------------------------TNGT-------------------------------------------------------------PC-----------------------------------------------VVVE-----------------------------GSGRVADVIA-------------------------------------QVANLPVS-------------------DITISL-------IQQKLSVFFQEMF----------ETFTE-------------------SRIVEWTKKIQDIVRRRQL-----------------------------------------------LTV-----------------------------------F-REGKDGQQDVDVAILQAL--LKASRSQDHF---GHENWDHQLKLAVA-------------------------WNRVDIARS-----------------------------EIFMDEWQWK-----------------------------------------------------------PSDLHPTMTAALISN--KP-------------------------------------------------------------EFVKL---------------------------------------------------FLENGVQL------------------------KEFVTWDTLLYLYENLD------------------PSCLFHSKLQKVLVED------------------PERPACAPA----APR-----------------------LQMHHVAQVL------------RELLGDFTQPLYPRPR-HN------------------------DRLRL------------------LLPVPHVKLNVQGVSLRSLY------------------------------------------KRSSGHVTFTM-----------------DPIR--------------------------------------------------DLL-IWA----IVQNRRELAGIIWAQSQDC--------------IAAALAC--------------SKI----------LKELS--------------KE-EEDT------------DSSEE----------------MLALAE-EYEH---RAIGV-------------------FTECYRKD--------------------------------------------EERAQK--------------------------LLTRVS---------------------------------------------------------------------EAWGKTTCLQLALEAK--------------DMKFVS--------------HGGIQAFLTKVWW-------------GQLS------------------------------VDNGL----------------------WRVTLC--MLAFPLLLT------------------GLISF-----------------------------------------------------------------------------REKRLQDVGTPAARARAFFT-------AP-------VVVFHLNILSYF-----AFL------------------------CLFAYVLMVDFQPV----------PSWCEC--------------------------AI-----------------------------------------------------------------------YLW--------------------------------------------LFSLVCEEM------RQLFYDPDEC------G-----LMKKAAL---YFSDFWNKLDVGAILLFVAGLTCRL------------------------------------------------------------IPA------TLYPG------RVILSLDFILFC-------------------------------------LRLMHIFTISKTLGPKII----------IVKRMMKD-VFF-------FLFLLAVWVVS---------------------------FGVAKQ----------AIL-------IHNERRV--------------------DWLFRGAVYHSYLTIFGQI----PGYIDGVNFNP-EHCSPNGTDP-----YKP-----KCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFN----------------------YTFQQVQE-------HTDQI-----------------------------------------------------W---------------KFQRH-------------DLIEEYHGR-----------------------------------------------------------------------------------------------PA---------------------------APPPFILLS-----------------------HLQLFI-----------------KRVVLK-----------------------TPAKRHKQLKNKLEKNEEAALLSWEIYLKE------------NYLQNRQFQQKQRPEQKIEDISNKVDAMVD-LLDLDPLK-RSGSMEQRLASLEEQVAQTAQALHWIVRTLRAS----GFSS-EADVPTLASQKA-AEEPDAEP-------------------------------------GG-------RKKTEEPGDSYHVNARHL--------------------LYPNCPVTRFPVPNEK------------VPWE------------------------------------------------------------------------------------------------------------------------TEFLIYDPP----------------------------------------------FYT---------A-ERKDAAAMDPMGDTLEPLSTIQYNVVDGL------------------------------------------------------------------------------------------------------RDRRSFHGPYTVQAGLPL---------------------------NPMGRTGLRGRGSLSCF---------GPNHTLY-------------------------P-------MVTRWRRNED------------------------------G---------------------------------AICRKSIKK-------MLEVLVVKLPL-------------------------SEHWALPGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWIETVAVSVHFQ------------DQND----------------VELNRLNSNL------------------HACDSGASIRWQVVDRRIPLYANHKT-------------------------LLQKAAAEFGAHY--- familyTRM-geneTRPM8 -MSFRAARLSMRNRRNDT----LD----------------------------STRTLYS------------------------------------SASRSTDL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S--------------------------------------------------------------------------------------------------------------------------------------------YSESDLVNFIQAN-------------FKKRECVFFT------------------KDSK--ATENV---------------------------------CKCGYAQSQHMEG----------------------------------------------TQINQSEKWNYKKHTKEFPTDA-------------------------------FGDIQFETLGKK--GKYIRLSC---------DTDAEILYELLTQHWHLK--------------------------------------------------------------------------------------------------------TPNLVIS-------------------------------VTGGAKN---FALKP----------RMRKIFSR-LIY----------------------------IAQSKGAWI---------------------------------------------------------LTGGT-------------------------------------------------------HYGLMK-YIGEV------------------------VRDNTISRSSEE-----------NIVAIGIAA--------W-----------GMVSNRDTLIR---NCDAEGYFLAQYLMDD---------FTRDPL--YILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERT---------------------------------------------------IQDS--------------------------------------------------NYGGKIPIVCFAQGG-----------------GKETLKAINTSI------------------------------------------------------------------------------------------KNKI-------------------------------------------------------------PC-----------------------------------------------VVVE-----------------------------GSGQIADVIA-------------------------------------SLVEVED--------------------ALTSSA-------VKEKLVRFLPRTV----------SRLPE-------------------EETESWIKWLKEILECSHL-----------------------------------------------LTV-----------------------------------I-KMEEAGDEIVSNAISYAL--YKAFSTSEQD----KDNWNGQLKLLLE-------------------------WNQLDLAND-----------------------------EIFTNDRRWE-----------------------------------------------------------SADLQEVMFTALIKD--RP-------------------------------------------------------------KFVRL---------------------------------------------------FLENGLNL------------------------RKFLTHDVLTELFSNHF-------------------STLVYRNLQIAK------------------------------------------------------------NSYNDALLTFV-----------WKLVANFRRGFRKEDR-----------------------------------------------------------------------------------------------------------------NGRDEMDIELHDV---------SPITRHPLQ--------------------------------------------------ALF-IWA----ILQNKKELSKVIWEQTRGC--------------TLAALGA--------------SKL----------LKTLA--------------KV-KNDI------------NAAGE----------------SEELAN-EYET---RAVEL-------------------FTECYSSD--------------------------------------------EDLAEQ--------------------------LLVYSC---------------------------------------------------------------------EAWGGSNCLELAVEAT--------------DQHFIA--------------QPGVQNFLSKQWY-------------GEIS------------------------------RDTKN----------------------WKIILC--LFIIPLVGC------------------GFVSF-----------------------------------------------------------------------------RKKPVDKHKKLLWYYVAFFT-------SP-------FVVFSWNVVFYI-----AFL------------------------LLFAYVLLMDFHSV----------PHPPEL--------------------------VL-----------------------------------------------------------------------YSL--------------------------------------------VFVLFCDEV------RQWYVNGVN-----------------------YFTDLWNVMDTLGLFYFIAGIVFRL-----------H----------------------------------------------SSNKS------SLYSG------RVIFCLDYIIFT-------------------------------------LRLIHIFTVSRNLGPKII----------MLQRMLID-VFF-------FLFLFAVWMVA---------------------------FGVARQ----------GIL-------RQNEQRW--------------------RWIFRSVIYEPYLAMFGQV----PSDVDGTTYDF-AHCTFTGNE------SKP-----LCVELD-EHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFG----------------------YTVGTVQE-------NNDQV-----------------------------------------------------W---------------KFQRY-------------FLVQEYCSRLN--------------------------------------------------------------------------------------------------------------------------IPFPFIVFA-----------------------YFYMVVKKC--------------FKCCCK--------------------------EKNMESSVCCFKNEDNETLAWEGVMKE------------NYLVKINTKANDTSEEMR--------------HRFRQLDTKLNDLKGLLKEIANK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IK--------------------------------------------------------------------------------------------- familyTRM-geneTRPM4 -MVVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKEQSWIPKI-------------FKKKTCTTFI------------------VDST--DPGGTL--------------------------------CQCGRPRTAHPAV--------------------------------A--M-------EDAFGAAVVTVWDSDAHTTEKPTDA-------------------------------YGELDFTGAGRK-HSNFLRLSD---------RTDPAAVYSLVTRTWGFR--------------------------------------------------------------------------------------------------------APNLVVS-------------------------------VLGGSGG---PVLQT----------WLQDLLRRGLVR----------------------------AAQSTGAWI---------------------------------------------------------VTGGL-------------------------------------------------------HTGIGR-HVGVA------------------------VRDHQMASTGGT-----------KVVAMGVAP--------W-----------GVVRNRDTLIN------PKGSFPARYRWRG---DPEDG------V-QFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQK---------------------------------------------------TGVG--------------------------------------------------GTGIDIPVLLLLIDG-----------------DEKMLTRIENAT------------------------------------------------------------------------------------------QAQL-------------------------------------------------------------PC-----------------------------------------------LLVA-----------------------------GSGGAADCLA---------------------------------------ETLED--------------------TLAPGSGGARQGEARDRIRRFFPK------------------------------------GDLEVLQAQVERIMTRKEL-----------------------------------------------LTV-----------------------------------Y--SSEDGSEEFETIVLKAL--VKACGSSEA------SAYLDELRLAVA-------------------------WNRVDIAQS-----------------------------ELFRGDIQWR-----------------------------------------------------------SFHLEASLMDALLND--RP-------------------------------------------------------------EFVRL---------------------------------------------------LISHGLSL------------------------GHFLTPMRLAQLYSAA------------------PSNSLIRNLLDQAS---------------------HSAGTKAPALKGGAAE-----------------------LRPPDVGHVL------------RMLLGKMCAPRYPSGG-A------------------------------------------------WDPHPGQGFGESMYLLS---------------------------------------------DKATSPLSLDA-------------GLGQAPWS--------------------------------------------------DLL-LWA----LLLNRAQMAMYFWEMGSNA--------------VSSALGA--------------CLL----------LRVMA--------------RL-EPDA------------EEAAR----------------RKDLAF-KFEG---MGVDL-------------------FGECYRSS--------------------------------------------EVRAAR--------------------------LLLRRC---------------------------------------------------------------------PLWGDATCLQLAMQAD--------------ARAFFA--------------QDGVQSLLTQKWW-------------GDMA------------------------------STTPI----------------------WALVLA--FFCPPLIYT------------------RLITF--------------RKSEEEPTREELE--FDMDSVINGEGPVGTADPAEKTPLGVPRQSG---------RPG-----CCGGRCGGRRCLRRWFHFWG-------AP-------VTIFMGNVVSYL-----LFL------------------------LLFSRVLLVDFQPAP---------PGSLEL--------------------------LL-----------------------------------------------------------------------YFW--------------------------------------------AFTLLCEEL------RQGLSGGGGSLASGGPGPGHASLSQRLRL---YLADSWNQCDLVALTCFLLGVGCRL------------------------------------------------------------TPG------LYHLG------RTVLCIDFMVFT-------------------------------------VRLLHIFTVNKQLGPKIV----------IVSKMMKD-VFF-------FLFFLGVWLVA---------------------------YGVATE----------GLL-------RPRDSDF--------------------PSILRRVFYRPYLQIFGQI---PQEDMDVALMEH-SNC---SSEPGFWA-HPPGAQAGTCV--------SQYANWLVVLLLVIFLLVANILLVNLLIAMFS----------------------YTFGKVQG-------NSDLY-----------------------------------------------------W---------------KAQRY-------------RLIREFHSR-----------------------------------------------------------------------------------------------PA---------------------------LAPPFIVIS-----------------------HLRLLL-----------------RQLCRRPRSPQ------------------PSSPALEHFRVYLSKEAERKLLTWESVHKE------------NFLLARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EALSRSAL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPPGGPPPP-------------------------------------------------------------------DLPG-----------------------SKD------------------------------------------------------------------------------------- familyTRM-geneTRPM5 -MQ-----------------------------------------------------------------------------------------------------------------------------------------------DVQGPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGSP--------------------------GD------------AEDRRELGLH------------------------------------------------------------------------------------------------------RGEVNFGGSGKK-RGKFVRVPS---------GVAPSVLFDLLLAEWHLP--------------------------------------------------------------------------------------------------------APNLVVS-------------------------------LVGEEQP---FAMKS----------WLRDVLRKGLVK----------------------------AAQSTGAWI---------------------------------------------------------LTSAL-------------------------------------------------------RVGLAR-HVGQA------------------------VRDHSLASTSTKV----------RVVAVGMAS---------L----------GRVLHRRILEE------AQEDFPVHY--------PEDDGGSQGPL--CSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQR---------------------------------------------------AGYGG-------------------------------------------------TGSIEIPVLCLLVNG-----------------DPNTLERISRAV------------------------------------------------------------------------------------------EQAA-------------------------------------------------------------PW-----------------------------------------------LILV-----------------------------GSGGIADVLA-------------------------------------ALVNQPH--------------------LLVPKV-------AEKQFKEKFPSK------------HFSW-------------------EDIVRWTKLLQNITSHQHL-----------------------------------------------LTV-----------------------------------Y-DFEQEGSEELDTVILKAL--VKACKSHSQE----PQDYLDELKLAVA-------------------------WDRVDIAKS-----------------------------EIFNGDVEWK-----------------------------------------------------------SCDLEEVMVDALVSN--KP-------------------------------------------------------------EFVRL---------------------------------------------------FVDNGADV------------------------ADFLTYGRLQELYRSVS------------------RKSLLFDLLQRKQEEARL-----------TLAGLGTQQAREPP---AGPPA----------------------FSLHEVSRVL------------KDFLQDACRGFYQDGR------------------------------------------------------PGDRRRAEKGPAK---------------------------------------------RPTGQKWLLDL------------NQKSENPWR--------------------------------------------------DLF-LWA----VLQNRHEMATYFWAMGQEG--------------VAAALAA--------------CKI----------LKEMS--------------HL-ETEA------------EAARA----------------TREA---KYER---LALDL-------------------FSECYSNS--------------------------------------------EARAFA--------------------------LLVRRN---------------------------------------------------------------------RCWSKTTCLHLATEAD--------------AKAFFA--------------HDGVQAFLTRIWW-------------GDMA------------------------------AGTPI----------------------LRLLGA--FLCPALVYT------------------NLITF----------------SEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQG-------------------DRGPRAVFLLTRWRKFWG-------AP-------VTVFLGNVVMYF-----AFL------------------------FLFTYVLLVDFRPPPQG-------PSGPEV--------------------------TL-----------------------------------------------------------------------YFW--------------------------------------------VFTLVLEEI------RQGFFTDEDT-----------HLVKKFTL---YVGDNWNKCDMVAIFLFIVGVTCRM------------------------------------------------------------LPS------AFEAG------RTVLAMDFMVFT-------------------------------------LRLIHIFAIHKQLGPKII----------VVERMMKD-VFF-------FLFFLSVWLVA---------------------------YGVTTQ----------ALL-------HPHDGRL--------------------EWIFRRVLYRPYLQIFGQI---PLDEIDEARVN----C---STHPLLLE-DSP-----SCP--------SLYANWLVILLLVTFLLVTNVLLMNLLIAMFS----------------------YTFQVVQG-------NADMF-----------------------------------------------------W---------------KFQRY-------------NLIVEYHER-----------------------------------------------------------------------------------------------PA---------------------------LAPPFILLS-----------------------HLSLTL-----------------RRVFKK-----------------------EAEHKREHLERDLPDPLDQKVVTWETVQKE------------NFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQ---------------------------------------------------------------------------GGGP-----RSSQHCGEGSQLV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AADHRGGLD-------------------------------------------------------------------------------------------------G----------------------------------------------------------------------------------------WEQPGAGQPPSDT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ familyTRPP-geneTRPP1 -MVNSSRV------------------------------------------------------------------------------------------------------------------------------------------QPQQPG---------------------------------------------------------------------------------------------------------------------------------DAK-------------------------------------RPPA---------------------------------------------------------------------------------------------------------------------------------------------------------PRAP--DPGRLMAGCAAV------------GASL----------AAPGGLCEQ---------------------------------------------------RGLEIEMQRIRQAAARDPPAG------------------------------------------------------------AAASPSPPLSSCSRQAWSRD--------------------------------------------------------------------------------------------------------NPGFEAEEEEEE--------------------------VEGEEGGM-V--------------VEMDVEWRPGSRRS---------------------------AASSAVSSVGARSRGLGGYHGA-GHPSGRRRRREDQ---------GPPC---PSP-----------VGGGD-PLHR-----------------------------------------------HLPLEGQPP-RVAWA-----------------------------------------------ERLVRGLRG-------LW-----------G----------------------------------------------TRLMEE-----SSTNR---------------EKYLKSVL------------------------------------------------------------------------------------------------------------RELVTYLL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLIVL---------------------------------------------------------------------------CILTY----------------------GMMSSN----------------------------------------------------V--------YYYTRMMSQLFL---------------------------------------------------------------------------------------DTPVSKTEKTNFKTLSSM-------------------------------------------------------------------------------------------------EDFWK--------------------------------------------------------------------------------------------------------------------------------------------FTEG---------------------------------------------------SLLDGLYW------------------------KMQPSNQTEAD--NRSF---------------------IFYENLLLGVP--------------------RIRQLRVRN-----------------------------------------------------------------------------------------------GSCS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPQDLRD--------------------------EIKECY--------------DV-YSVS---------------------------------SEDRAP--------FGPRNG------------------TAWIYTSE--------------------------------------------KDLNGS-----------------------------------------------------------------------------------------------------SHWGIIATYSGAGYYL----------DLSRTREETAAQV---------------ASLKKNVWL----------------------------------------------DRGTRA----------------------TFIDFS--VYNANINLF------------------CVVRLLV----------------EFPATGGV---------------------------------------------------------------------------------------IPSWQFQPLKLI-------------------------------RYVTTFDFFLAACEIIF----------------------C-----------------FF----------------------------------------------------------------------------------------------------------------------IFYYVVEEI------LEIRIHKLH-----------------------YFRSFWNCLDVVIVVLSVVAIGINI------------------------------------YRTSNVEVLL----QFLEDQNTFPNFE------HLAYWQIQF--NNIAAVTVFFVW-------------------------------------IKLFKFINFNRTMSQLST----------TMSRCAKD-LFG-------FAIMFFIIFLA---------------------------YAQLAY----------LVF--------------------------------GTQVDDFSTFQECIFTQFRII----LGDINFAEIE-------------------------E------------ANRVLGPIYFTTFVFFMFFILLNMFLAIIN----------------------DTYSEVKS-------DLA-Q--------------------------------------------------------------------QKAEMELS-----------DLIRKGYHKA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVKLKLKKNTVDDISESLRQGGGKLNF------------DELRQDLKGKGHTDAEI---EAIFTKYDQD--GDQELTEHEHQQMRDDLEKERED--------------LDLDH--------SSLPRPMSSRSFPRSLDDSEEDDD-------------------E-----------------------DSGHSSRRRGSISSGV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SYEEFQV---------------------LVRRVDRMEHSIGSIVS------------------------------------------------------------------------------------------------------------------KIDAVIVK--L------------------------EIMERAKLKRRE------------VLGR------LLDGVAE-------------------------DERLGRDSEI---------------------------------------------------------------------------------------------------------------------HREQMERLVREELERWES----------------------------------------DDAASQISHGLGT-------PVGLNG-----------------QPRPRSSRP------------------SSSQSTEGMEGAGGNGSSNVHV--------------------------------------------- familyTRPP-geneTRPP2 -MNAVGS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEGQ---------------------------------------------------------------------------------------------------------ELQKLGSGAWDNPAYS------------------------------------------------------------GPPSPHGTLRVCTISSTGPL-QP-----------------------------------------------------------------------------------------------------QPKKPEDEPQET-------------------------------------------------------------------------------------------AYRTQVSSC---------------------------------------C----------------------------------------------------------------------------------------------------------------------------------------LHICQGIRG-------LW-----------G----------------------------------------------TTLTEN-----TAENR---------------ELYIKTTL------------------------------------------------------------------------------------------------------------RELLVYIV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLVDI---------------------------------------------------------------------------CLLTY----------------------GMTSSS----------------------------------------------------A--------YYYTKVMSELFL-----------------------------------------------------------------------------------------HTPSDTGVSFQAISSM-------------------------------------------------------------------------------------------------ADFWD--------------------------------------------------------------------------------------------------------------------------------------------FAQG---------------------------------------------------PLLDSLYW------------------------TKWYNNQSLGHGSHSF----------------------IYYENMLLGVP--------------------RLRQLKVRN-----------------------------------------------------------------------------------------------DSCV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHEDFRE--------------------------DILSCY--------------DV-YSPD---------------------------------KEEQLP--------FGPFNG------------------TAWTYHSQ--------------------------------------------DELGGF-----------------------------------------------------------------------------------------------------SHWGRLTSYSGGGYYL----------DLPGSRQGSAEAL---------------RALQEGLWL----------------------------------------------DRGTRV----------------------VFIDFS--VYNANINLF------------------CVLRLVV----------------EFPATGGA---------------------------------------------------------------------------------------IPSWQIRTVKLI-------------------------------RYVSNWDFFIVGCEVIF----------------------C-----------------VF----------------------------------------------------------------------------------------------------------------------IFYYVVEEI------LELHIHRLR-----------------------YLSSIWNILDLVVILLSIVAVGFHI------------------------------------FRTLEVNRLM---GKLLQQPNTYADFE------FLAFWQTQY--NNMNAVNLFFAW-------------------------------------IKIFKYISFNKTMTQLSS----------TLARCAKD-ILG-------FAVMFFIVFFA---------------------------YAQLGY----------LLF--------------------------------GTQVENFSTFIKCIFTQFRII----LGDFDYNAID-------------------------N------------ANRILGPAYFVTYVFFVFFVLLNMFLAIIN----------------------DTYSEVKE-------ELAGQ---------------------------------------------------------------------KDELQLS-----------DLLKQGYNKT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLRLRLRKERVSDVQKVLQGGEQEIQF------------EDFTNTLRELGHAEHEITELTATFTKFDRD--GNRILDEKEQEKMRQDLEEERVA--------------LNTEI--------EKLGRSIVSSPQ----------------------------------------------G--------KSGPEAARAGGWVSG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEFYM---------------------LTRRVLQLETVLEGVVS------------------------------------------------------------------------------------------------------------------QIDAVGSK--L------------------------KMLERKGWLA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSPGVKEQAIWKH----------------------------------------PQPAPAVT---PD-------PWGVQGG---------------QESEVPYKRE-----------------EEALEERRLSRGEIPTLQRS------------------------------------------------ familyTRPP-geneTRPP3 -MAEASR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WHR---------GGASK------------------------------------------HKLHYRK------------------------EVEITTTL------------------------------------------------------------------------------------------------------------QELLLYFI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLINL---------------------------------------------------------------------------CILTF----------------------GMVNPH----------------------------------------------------M--------YYLNKVMSSLFL---------------------------------------------------------------------------------------DTSVPGEERTNFKSIRSI-------------------------------------------------------------------------------------------------TDFWK--------------------------------------------------------------------------------------------------------------------------------------------FMEG---------------------------------------------------PLLEGLYW------------------------DSWYNNQQLYNLKNSSR---------------------IYYENILLGVP--------------------RVRQLKVRN-----------------------------------------------------------------------------------------------NTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYSSFQS--------------------------LMSECY--------------GK-YTSA---------------------------------NEDLSN--------FGLQIN------------------TEWRYSTSNT--------------------------------------------------------------------------------------------------------------------------------------------------NSPWHWGFLGVYRNGGYIF----------TLSKSKSETKNKF---------------IDLRLNSWI----------------------------------------------TRGTRV----------------------IFIDFS--LYNANVNLF------------------CIIRLVA----------------EFPATGGI---------------------------------------------------------------------------------------LTSWQFYSVKLL-------------------------------RYVSYYDYFIASCEITF----------------------C-----------------IF----------------------------------------------------------------------------------------------------------------------LFVFTTQEV------KKIKEFKSA-----------------------YFKSIWNWLELLLLLLCFVAVSFNT------------------------------------YYNVQIFLLL---GQLLKSTEKYSDFY------FLACWHIYY--NNIIAITIFFAW-------------------------------------IKIFKFISFNKTMSQLSS----------TLSRCVKD-IVG-------FAIMFFIIFFA---------------------------YAQLGF----------LVF--------------------------------GSQVDDFSTFQNSIFAQFRIV----LGDFNFAGIQ-------------------------Q------------ANPILGPIYFITFIFFVFFVLLNMFLAIIN----------------------DTYSEVKA-------DYSIG--------------------------------------------------------------------RRLDFELG-----------KMIKQSYKNV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEKFRLKKAQKDEDKKTKGSG-------------------DLAEQARREGFDENEI-------------------QNAEQMKKWKERLEKKYYS---------------------------MEIQDDYQPVTQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEFRE---------------------LFLYAVELEKELHYINL------------------------------------------------------------------------------------------------------------------KLNQVVRK--V---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAL---------------------------------------------------------------- familyTRML-geneTRPML1 -MTAP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-GPRGSET-------------------------------------------------------------------------------------------ERLLTPNPGYGTQAGPSP-----------------------------------------------------------------APPTPPEEEDLRRRLKYFF---------------------------------------------------------------------------------------------------------------------------------------------------------MSP--------------------------------------------------------------------------------------------------CD---------------------------------------------------------------------------------------------------------------------------------------KFRAKGRKP--------C---------------------------------------------------------KLMLQVVK------------------------ILVVTVQL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILFGLS------------------------------------------NQLAV----------------------TFREENT------------------------------------------------------------IAFRHLFLLGYSDGAD-------------------------------------------DTF---------------------------------------AAYTREQLYQAIFHAV----------------------DQYLALP---------------------------DVSLGRY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AYVRGGGD----------------------------------------------PWTNGSGLAL-----------------------CQRYYHRGHVDPANDTFD-----------------IDPMVVTDCIQVDPPE-------------------RPP--PPPS-----------------------------------------------------------------------------------------------DDLTLL----------------------------------------------------------------------------ESSS-SYKNLTLKFHKL----------------------------------------------------------------------------------------------------------------VNVTIHF--------------------------RLKTIN--------------------------------------------------------------------------------------------LQSLINNE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPDCYTFSVLITF------DN--------------------------------------KAHSGR----------------------IPISLE-----------------------------TQAHI------------------------------------------------------------------QECK----------------------------------HP------SVFQHGDNSFRLL---FDVVV-----------------------ILTCSLSFLLCARSLLRG---------------------------------------FLLQNE------------------------------------------------------------------------------------------------------------------FVGFMWRQR-----GRVISLWERL-----------------------EFVNGWYILLVTSDVLTISGTIMKI----------------------------------------------------------GIEAK------NLASYDV---CSILLGTSTLLVW-------------------------------------VGVIRYLTFFHNYNILIA----------TLRVALPS-VMR-------FCCCVAVIYLG---------------------------YCFCGW----------IVL--------------------------------GPYHVKFRSLSMVSECLFSLI---NGDDMFVTFAAM-----------------------------QAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALIT----------------------GAYDTIKHPGGAGAEESELQ----------------------------------------------------AY-------------IAQCQDS-------------PTSGKFRRGSG---------------------------------------------------------------------------------------------SA----------------------------------------------------------------------------------CSLLCCCG-------------------------------------------------------------------------------------------------------------------------------------------------RDPSEEHSLLVN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- familyTRML-geneTRPML2 -MARQPYRF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQARI-PERGSG------------------------------------------------------------------------------------------------VFRLTVRNAMA--------------------------------------------------------------------HRDSEMKEECLREDLKFYF---------------------------------------------------------------------------------------------------------------------------------------------------------MSP--------------------------------------------------------------------------------------------------CE---------------------------------------------------------------------------------------------------------------------------------------KYRARRQIP--------W---------------------------------------------------------KLGLQILK------------------------IVMVTTQL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRFGLS------------------------------------------NQLVV----------------------AFKEDNT------------------------------------------------------------VAFKHLFLKGYSGTDE-------------------------------------------DDY-------------------------------------SCSVYTQEDAYESIFFAI----------------------NQYHQLK---------------------------DITLGTL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYGEN--------------------------------------------------EDNRIGLKV-----------------------CKQHYKKGTMFPSNETLN-----------------IDNDVELDCVQL-DLQ-------------------DLSKKPPDW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNSSFFRLEFYRL----------------------------------------------------------------------------------------------------------------LQVEISF--------------------------HLKGID--------------------------------------------------------------------------------------------LQTIHSRE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPDCYVFQNTIIF------DN--------------------------------------KAHSGK----------------------IKIYFD-----------------------------SDAKI------------------------------------------------------------------EECKDLN----------------------------------------IFGSTQKNAQYV-LVFDAFV-----------------------IVICLASLILCTRSIVLA---------------------------------------LRLRKR------------------------------------------------------------------------------------------------------------------FLNFFLEKY-----KRPVCDTDQW-----------------------EFINGWYVLVIISDLMTIIGSILKM----------------------------------------------------------EIKAK------NLTNYDL---CSIFLGTSTLLVW-------------------------------------VGVIRYLGYFQAYNVLIL----------TMQASLPK-VLR-------FCACAGMIYLG---------------------------YTFCGW----------IVL--------------------------------GPYHDKFENLNTVAECLFSLV---NGDDMFATFAQI--------------------------------QQKSILVWLFSRLYLYSFISLFIYMILSLFIALIT----------------------DSYDTIKKFQQNGFPETDLQ----------------------------------------------------EF-------------LKECS----------------SKEEYQKESS---------------------------------------------------------------------------------------------AF----------------------------------------------------------------------------------LSCICCRR-------------------------------------------------------------------------------------------------------------------------------------------------RKRSDDHLIPIS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- familyTRML-geneTRPML3 -MADPEVVV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSCSS-HEEEN---------------------------------------------------------------------------------------------------RCNFNQQTS--------------------------------------------------------------------PSEELLLEDQMRRKLKFFF---------------------------------------------------------------------------------------------------------------------------------------------------------MNP--------------------------------------------------------------------------------------------------CE---------------------------------------------------------------------------------------------------------------------------------------KFWARGRKP--------W---------------------------------------------------------KLAIQILK------------------------IAMVTIQL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLFGLS------------------------------------------NQMVV----------------------AFKEENT------------------------------------------------------------IAFKHLFLKGYMDRMD-------------------------------------------DTY---------------------------------------AVYTQSDVYDQLIFAV----------------------NQYLQLY---------------------------NVSVGNH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AYENK--------------------------------------------------GTKQSAMAI-----------------------CQHFYKRGNIYPGNDTFD-----------------IDPEIETECFFV-EPD-------------------EPFHIGTPA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENKLNLTLDFHRL----------------------------------------------------------------------------------------------------------------LTVELQF--------------------------KLKAIN--------------------------------------------------------------------------------------------LQTVRHQE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPDCYDFTLTITF------DN--------------------------------------KAHSGR----------------------IKISLD-----------------------------NDISI------------------------------------------------------------------RECKDWH----------------------------------------VSGSIQKNTHYM-MIFDAFV-----------------------ILTCLVSLILCIRSVIRG---------------------------------------LQLQQE------------------------------------------------------------------------------------------------------------------FVNFFLLHY-----KKEVSVSDQM-----------------------EFVNGWYIMIIISDILTIIGSILKM----------------------------------------------------------EIQAK------SLTSYDV---CSILLGTSTMLVW-------------------------------------LGVIRYLGFFAKYNLLIL----------TLQAALPN-VIR-------FCCCAAMIYLG---------------------------YCFCGW----------IVL--------------------------------GPYHDKFRSLNMVSECLFSLI---NGDDMFATFAKM--------------------------------QQKSYLVWLFSRIYLYSFISLFIYMILSLFIALIT----------------------DTYETIKQYQQDGFPETELR----------------------------------------------------TF-------------ISECKDL-------------PNSGKYRLEDD---------------------------------------------------------------------------------------------PP----------------------------------------------------------------------------------VSLFCCCK-------------------------------------------------------------------------------------------------------------------------------------------------K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ; end; begin trees; tree tree_1 = [&U] [&branchAttributeNames={"FastTree support value"}](familyTRPP-genePK1L2:0.6568199999999997,familyTRPP-genePK1L3:0.8477199999999998,(familyTRPP-genePKD1:1.1246999999999998,(familyTRPP-genePKDREJ:1.29284,(familyTRPP-genePK1L1:1.3947699999999998,(((((familyTRM-geneTRPM1:0.25184000000000006,familyTRM-geneTRPM3:0.18375999999999992)[&"FastTree support value"=0.999]:0.16845,(familyTRM-geneTRPM6:0.32706999999999997,familyTRM-geneTRPM7:0.24632999999999994)[&"FastTree support value"=1.0]:0.21308000000000016)[&"FastTree support value"=1.0]:0.51633,((familyTRM-geneTRPM4:0.4855100000000001,familyTRM-geneTRPM5:0.4059300000000001)[&"FastTree support value"=1.0]:0.2773300000000001,(familyTRM-geneTRPM2:0.46457999999999977,familyTRM-geneTRPM8:0.5970499999999999)[&"FastTree support value"=0.978]:0.14002999999999988)[&"FastTree support value"=1.0]:0.2979799999999999)[&"FastTree support value"=1.0]:0.7208299999999999,((familyTRML-geneTRPML1:0.2879900000000002,(familyTRML-geneTRPML2:0.4416500000000001,familyTRML-geneTRPML3:0.1937899999999999)[&"FastTree support value"=0.905]:0.17257999999999996)[&"FastTree support value"=1.0]:1.5793499999999998,(familyTRPP-geneTRPP3:0.38576999999999995,(familyTRPP-geneTRPP1:0.3544299999999998,familyTRPP-geneTRPP2:0.4092500000000001)[&"FastTree support value"=0.947]:0.1649799999999999)[&"FastTree support value"=1.0]:1.0809699999999998)[&"FastTree support value"=0.948]:0.3122600000000002)[&"FastTree support value"=0.931]:0.1741299999999999,((familyTRPN-geneNompc:1.0127099999999998,(familyTRPA-geneTRPA1:1.1082100000000001,((familyTRPV-geneTRPV5:0.17222999999999988,familyTRPV-geneTRPV6:0.09492000000000012)[&"FastTree support value"=1.0]:0.74668,(familyTRPV-geneTRPV3:0.5437599999999998,(familyTRPV-geneTRPV4:0.4088099999999999,(familyTRPV-geneTRPV1:0.3062900000000002,familyTRPV-geneTRPV2:0.53539)[&"FastTree support value"=0.997]:0.15898000000000012)[&"FastTree support value"=0.965]:0.12455000000000016)[&"FastTree support value"=0.997]:0.3936099999999998)[&"FastTree support value"=1.0]:0.63754)[&"FastTree support value"=0.785]:0.2613599999999998)[&"FastTree support value"=0.999]:0.5888499999999999,((familyTRC-geneTRPC1:0.54406,(familyTRC-geneTRPC4:0.1669299999999998,familyTRC-geneTRPC5:0.1934300000000002)[&"FastTree support value"=1.0]:0.22601000000000004)[&"FastTree support value"=0.997]:0.21939999999999982,((familyTRC-geneTRPC6:0.13099000000000016,(familyTRC-geneTRPC3:0.10610000000000008,familyTRC-geneTRPC7:0.09019999999999984)[&"FastTree support value"=0.972]:0.0838000000000001)[&"FastTree support value"=1.0]:0.45779000000000014,familyTRC-geneTRPC2:0.7957399999999999)[&"FastTree support value"=0.886]:0.10847999999999969)[&"FastTree support value"=1.0]:0.5180700000000003)[&"FastTree support value"=0.294]:0.11532000000000009)[&"FastTree support value"=1.0]:0.59396)[&"FastTree support value"=0.958]:0.17781000000000002)[&"FastTree support value"=0.994]:0.2479800000000001)[&"FastTree support value"=0.996]:0.19991000000000003); end;